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短与长 Roux 袢长度在 Roux-en-Y 胃旁路手术治疗病态肥胖和超级肥胖:文献系统回顾。

Short versus long Roux-limb length in Roux-en-Y gastric bypass surgery for the treatment of morbid and super obesity: a systematic review of the literature.

机构信息

Visceral Surgery, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211, Geneva 4, Switzerland.

出版信息

Obes Surg. 2011 Jun;21(6):797-804. doi: 10.1007/s11695-011-0409-y.

Abstract

Because of an important burden of disease, obesity is a major public health challenge in the twenty-first century. Where medico-psychological management has shown its limitations, bariatric surgery is now acknowledged as the most efficient therapy potentially offered to severely obese patients. Among other options, Roux-en-Y gastric bypass (RYGBP) is the most frequently performed procedure. The objective of this review is to systematically evaluate the effect of the Roux- (alimentary) limb length on postoperative weight loss after RYGBP in severely obese patients. MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched using terms related to Roux-limb, gastric bypass and obesity. To be included, studies had to be either randomized controlled trials, quasi-randomized controlled trials or prospective cohort studies comparing a shorter to a longer Roux-limb. Studies were critically appraised with regard to methodological components. Eight studies were reviewed. Variations in methodology, operation design and outcome assessment among studies caused considerable clinical heterogeneity, preventing us from performing a meta-analysis. The overall quality was questionable, owing to lack of rigor in methodological components reporting. Results were heterogeneous, but we identified a trend supporting that the construction of a longer Roux-limb is more efficient in super obese patients. This review suggests that the tailoring of a longer Roux-limb might only be efficient in super obese patients. The overall limited quality of the included studies prompts to call for improvement in trial design in surgery.

摘要

由于肥胖症带来的巨大疾病负担,它已成为 21 世纪公共卫生领域的主要挑战之一。在医学心理管理方法已显示出其局限性的情况下,减重手术现在被认为是为严重肥胖患者提供的最有效的治疗方法。在其他选择中,Roux-en-Y 胃旁路术(RYGBP)是最常进行的手术。本综述的目的是系统评估 Roux (肠)支长度对 RYGBP 术后严重肥胖患者体重减轻的影响。使用与 Roux 支、胃旁路和肥胖相关的术语,在 MEDLINE、EMBASE 和 Cochrane 对照试验中心注册库(CENTRAL)中进行了检索。纳入的研究必须是比较短 Roux 支与长 Roux 支的随机对照试验、准随机对照试验或前瞻性队列研究。根据方法学组成部分对研究进行了批判性评价。综述了 8 项研究。由于研究之间的方法学、手术设计和结果评估存在差异,导致临床异质性很大,因此我们无法进行荟萃分析。由于缺乏方法学组成部分报告的严谨性,整体质量值得怀疑。结果存在异质性,但我们发现了一个支持在超级肥胖患者中构建更长 Roux 支更有效的趋势。本综述表明,量身定制更长的 Roux 支可能仅对超级肥胖患者有效。纳入研究的整体质量有限,促使人们呼吁在手术中改善试验设计。

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