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撤回:重度精神障碍患者的病例管理。

WITHDRAWN: Case management for people with severe mental disorders.

作者信息

Marshall Max, Gray Alastair, Lockwood Austin, Green Rex

机构信息

University of Manchester, The Lantern Centre, Vicarage Lane, Of Watling Street Road, Fulwood, Preston., Lancashire, UK.

出版信息

Cochrane Database Syst Rev. 2011 Apr 13;2011(4):CD000050. doi: 10.1002/14651858.CD000050.pub2.

Abstract

BACKGROUND

Since the 1960s, in many parts of the world, large psychiatric were closed down and people were treated in outpatient clinics, day centres or community mental health centres. Rising readmission rates suggested that this type of community care may be less effective than anticipated. In the 1970s case management arose as a means of co-ordinating the care of severely mentally ill people in the community.

OBJECTIVES

To determine the effects of case management as an approach to caring for severely mentally ill people in the community. Case management was compared against standard care on four main indices: (i) numbers remaining in contact with the psychiatric services; (ii) extent of psychiatric hospital admissions; (iii) clinical and social outcome; and (iv) costs.

SEARCH STRATEGY

Electronic searches of CINAHL (1997), the Cochrane Schizophrenia Group's Register of trials (1997), EMBASE (1980-1995), MEDLINE (1966-1995), PsycLIT (1974-1995) and SCISEARCH (1997) were undertaken. References of all identified studies were searched for further trial citations.

SELECTION CRITERIA

The inclusion criteria were that studies should be randomised controlled trials that (i) had compared case management to standard community care; and (ii) had involved people with severe mental disorder mainly between the ages of 18-65. Studies of case management were defined as those in which the investigators described the intervention as 'case' or 'care' management rather than 'Assertive Community Treatment' or 'ACT'.

DATA COLLECTION AND ANALYSIS

A study was carried out to test the reliability of the inclusion criteria. Categorical data were extracted twice and then cross-checked, any disagreements being resolved by discussion. Odds ratios and the number needed to treat were estimated. Continuous data collected by a measuring instrument was only included if the instrument (i) had been described in a peer-reviewed journal; (ii) was a self-report or had been completed by an independent rater; and (iii) provided a summary score for a broad area of functioning. Normally distributed continuous data were included if means and standard deviations were available. Non-normal data were included if analysed either after transformation or using non-parametric methods. Tests for heterogeneity were conducted.

MAIN RESULTS

Case management increased the numbers remaining in contact with services (for case management odds ratio = 0.70; 99%CI 0.50-0.98; n=1210). Case management approximately doubled the numbers admitted to psychiatric hospital (OR 1.84; 99% CI 1.33-2.57; n=1300). Except for a positive finding on compliance, from one study, case management showed no significant advantages over standard care on any psychiatric or social variable. Cost data did not favour case management but insufficient information was available to permit definitive conclusions.

AUTHORS' CONCLUSIONS: Case management ensures that more people remain in contact with psychiatric services (one extra person remains in contact for every 15 people who receive case management), but it also increases hospital admission rates. Present evidence suggests that case management also increases duration of hospital admissions, but this is not certain. Whilst there is some evidence that case management improves compliance, it does not produce clinically significant improvement in mental state, social functioning, or quality of life. There is no evidence that case management improves outcome on any other clinical or social variables. Present evidence suggests that case management increases health care costs, perhaps substantially, although this is not certain. In summary, therefore, case management is an intervention of questionable value, to the extent that it is doubtful whether it should be offered by community psychiatric services. It is hard to see how policy makers who subscribe to an evidence-based approach can justify retaining case management as 'the cornerstone' of community mental health care. Case management is compared to the main alternative approach (ACT) in a forthcoming Cochrane review.

摘要

背景

自20世纪60年代以来,在世界许多地区,大型精神病院被关闭,患者改在门诊诊所、日间中心或社区精神卫生中心接受治疗。再入院率的上升表明,这种社区护理方式的效果可能不如预期。20世纪70年代出现了病例管理,作为一种在社区协调重症精神病患者护理的手段。

目的

确定病例管理作为一种在社区护理重症精神病患者的方法的效果。将病例管理与标准护理在四个主要指标上进行比较:(i)与精神科服务机构保持联系的人数;(ii)精神病院住院率;(iii)临床和社会结局;(iv)成本。

检索策略

对CINAHL(1997年)、Cochrane精神分裂症研究组试验注册库(1997年)、EMBASE(1980 - 1995年)、MEDLINE(1966 - 1995年)、PsycLIT(1974 - 1995年)和SCISEARCH(1997年)进行了电子检索。对所有已识别研究的参考文献进行检索,以获取更多试验引用。

入选标准

入选标准为研究应为随机对照试验,(i)将病例管理与标准社区护理进行比较;(ii)主要涉及年龄在18 - 65岁之间的重症精神障碍患者。病例管理研究被定义为研究者将干预描述为“病例”或“护理”管理,而非“积极社区治疗”或“ACT”的研究。

数据收集与分析

进行了一项研究以检验入选标准的可靠性。分类数据提取两次,然后进行交叉核对,任何分歧通过讨论解决。估计优势比和需治疗人数。仅当测量工具(i)在同行评审期刊中有所描述;(ii)为自我报告或由独立评估者完成;(iii)提供了广泛功能领域的汇总分数时,才纳入通过测量工具收集的连续数据。如果有均值和标准差,则纳入正态分布的连续数据。如果在转换后或使用非参数方法进行分析,则纳入非正态数据。进行了异质性检验。

主要结果

病例管理增加了与服务机构保持联系的人数(病例管理的优势比 = 0.70;99%置信区间0.50 - 0.98;n = 1210)。病例管理使精神病院住院人数增加了约一倍(优势比1.84;99%置信区间1.33 - 2.57;n = 1300)。除了一项研究中关于依从性的积极发现外,病例管理在任何精神或社会变量上均未显示出比标准护理有显著优势。成本数据不支持病例管理,但可用信息不足,无法得出明确结论。

作者结论

病例管理确保更多人与精神科服务机构保持联系(每15名接受病例管理的人中就有1人多与服务机构保持联系),但也增加了住院率。现有证据表明,病例管理也会增加住院时间,但尚不确定。虽然有一些证据表明病例管理可提高依从性,但在精神状态、社会功能或生活质量方面并未产生临床上显著的改善。没有证据表明病例管理在任何其他临床或社会变量上能改善结局。现有证据表明,病例管理可能会大幅增加医疗保健成本,尽管尚不确定。因此,总的来说,病例管理是一种价值存疑的干预措施,以至于社区精神科服务机构是否应提供该服务都值得怀疑。很难理解那些信奉循证方法的政策制定者如何能将病例管理作为社区精神卫生护理的“基石”而加以保留。在即将发表的Cochrane综述中,将病例管理与主要的替代方法(ACT)进行了比较。

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