酵母中的Ras信号传导。
Ras signaling in yeast.
作者信息
Tamanoi Fuyuhiko
机构信息
Department of Microbiology, Immunology & Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA.
出版信息
Genes Cancer. 2011 Mar;2(3):210-5. doi: 10.1177/1947601911407322.
Abstract
Since the study of yeast RAS and adenylate cyclase in the early 1980s, yeasts including budding and fission yeasts contributed significantly to the study of Ras signaling. First, yeast studies provided insights into how Ras activates downstream signaling pathways. Second, yeast studies contributed to the identification and characterization of GAP and GEF proteins, key regulators of Ras. Finally, the study of yeast provided many important insights into the understanding of C-terminal processing and membrane association of Ras proteins.
摘要
自20世纪80年代初对酵母RAS和腺苷酸环化酶进行研究以来，包括芽殖酵母和裂殖酵母在内的酵母对Ras信号传导的研究做出了重大贡献。首先，酵母研究为Ras如何激活下游信号通路提供了见解。其次，酵母研究有助于鉴定和表征Ras的关键调节因子GAP和GEF蛋白。最后，酵母研究为理解Ras蛋白的C末端加工和膜结合提供了许多重要见解。
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