真核生物 5S rRNA 的生物发生。
Eukaryotic 5S rRNA biogenesis.
机构信息
Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY, USA.
出版信息
Wiley Interdiscip Rev RNA. 2011 Jul-Aug;2(4):523-33. doi: 10.1002/wrna.74. Epub 2011 Feb 25.
Abstract
The ribosome is a large complex containing both protein and RNA which must be assembled in a precise manner to allow proper functioning in the critical role of protein synthesis. 5S rRNA is the smallest of the RNA components of the ribosome, and although it has been studied for decades, we still do not have a clear understanding of its function within the complex ribosome machine. It is the only RNA species that binds ribosomal proteins prior to its assembly into the ribosome. Its transport into the nucleolus requires this interaction. Here we present an overview of some of the key findings concerning the structure and function of 5S rRNA and how its association with specific proteins impacts its localization and function.
摘要
核糖体是一种包含蛋白质和 RNA 的大型复合物，必须以精确的方式组装，以使其在蛋白质合成这一关键作用中正常发挥功能。5S rRNA 是核糖体 RNA 成分中最小的一种，尽管它已经被研究了几十年，但我们仍然不清楚它在复杂的核糖体机器中的功能。它是唯一在装配到核糖体之前与核糖体蛋白结合的 RNA 种类。其进入核仁的运输需要这种相互作用。在这里，我们概述了一些关于 5S rRNA 的结构和功能的关键发现，以及其与特定蛋白质的关联如何影响其定位和功能。
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本文引用的文献
1
The evolutionary history of the structure of 5S ribosomal RNA.
J Mol Evol. 2009 Nov;69(5):430-43. doi: 10.1007/s00239-009-9264-z. Epub 2009 Jul 29.
2
NOPdb: Nucleolar Proteome Database--2008 update.
Nucleic Acids Res. 2009 Jan;37(Database issue):D181-4. doi: 10.1093/nar/gkn804. Epub 2008 Nov 4.
3
Dicistronic tRNA-5S rRNA genes in Yarrowia lipolytica: an alternative TFIIIA-independent way for expression of 5S rRNA genes.
Nucleic Acids Res. 2008 Oct;36(18):5832-44. doi: 10.1093/nar/gkn549. Epub 2008 Sep 12.
4
Functional features of the C-terminal region of yeast ribosomal protein L5.
Mol Genet Genomics. 2008 Oct;280(4):337-50. doi: 10.1007/s00438-008-0369-7. Epub 2008 Aug 27.
5
Assembly of the Trypanosoma brucei 60S ribosomal subunit nuclear export complex requires trypanosome-specific proteins P34 and P37.
Eukaryot Cell. 2009 Jan;8(1):77-87. doi: 10.1128/EC.00234-08. Epub 2008 Aug 22.
6
Nucleolus: the ribosome factory.
Histol Histopathol. 2008 Oct;23(10):1291-8. doi: 10.14670/HH-23.1291.
7
Contribution of individual amino acids to the 5S RNA binding activity of the Xenopus zinc finger protein p43.
Biochemistry. 2008 Aug 12;47(32):8398-405. doi: 10.1021/bi800080c. Epub 2008 Jul 18.
8
The post-transcriptional steps of eukaryotic ribosome biogenesis.
Cell Mol Life Sci. 2008 Aug;65(15):2334-59. doi: 10.1007/s00018-008-8027-0.
9
Two distinct structural elements of 5S rRNA are needed for its import into human mitochondria.
RNA. 2008 Apr;14(4):749-59. doi: 10.1261/rna.952208. Epub 2008 Feb 26.
10
5S rRNA: Structure and Function from Head to Toe.
Int J Biomed Sci. 2005 Jun;1(1):2-7.
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