采用临床和实验室标准协会 M27-A3 肉汤微量稀释参考方法，通过与 48 小时测定比较，验证 24 小时氟胞嘧啶 MIC 测定的有效性。
Validation of 24-hour flucytosine MIC determination by comparison with 48-hour determination by the Clinical and Laboratory Standards Institute M27-A3 broth microdilution reference method.
机构信息
Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop G-11, Atlanta, GA 30333, USA.
出版信息
J Clin Microbiol. 2011 Dec;49(12):4322-5. doi: 10.1128/JCM.05479-11. Epub 2011 Oct 19.
Abstract
Flucytosine and itraconazole are the only antifungal agents for which the Clinical Laboratory and Standards Institute recommendations include MIC breakpoint readings at 48 h only. Here we show good essential and categorical agreement between the flucytosine MIC readings at 48 and 24 h for Candida species.
摘要
氟胞嘧啶和伊曲康唑是仅有的两种抗真菌药物，临床实验室标准化研究所的建议只包括在 48 小时时的 MIC 折点读数。在这里，我们显示了在 48 小时和 24 小时时氟胞嘧啶 MIC 读数之间对念珠菌属的良好的基本和分类一致性。
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