炎症性肠病对青春期生长的影响。

Impact of inflammatory bowel disease on pubertal growth.

机构信息

Developmental Endocrinology Research Group, University of Glasgow, Royal Hospital for Sick Children, Glasgow, UK.

出版信息

Horm Res Paediatr. 2011;76(5):293-9. doi: 10.1159/000329991. Epub 2011 Oct 18.

DOI:10.1159/000329991

PMID:22024935

Abstract

BACKGROUND

Puberty is thought to be commonly affected in adolescents with inflammatory bowel disease (IBD).

AIMS

To determine the impact of Crohn's disease (CD) and ulcerative colitis (UC) on the pubertal growth spurt.

METHODS

Retrospective study of 30 boys with CD (CD-M), 11 girls with CD (CD-F), 14 boys with UC (UC-M) and 12 girls with UC (UC-F). Pubertal growth was assessed by calculating peak height velocity SDS (PHV SDS), height SDS at diagnosis (Ht(Diag)) and height SDS at PHV (Ht(PHV)) and age at PHV (Age(PHV)). Systemic markers of disease activity were also collected.

RESULTS

Altered parameters of pubertal growth were observed in the CD groups compared to the normal population: in the CD-M group, median Ht(Diag) was -0.56 (p = 0.001) and median Age(PHV) was 14.45 years (p = 0.004), and in the CD-F group, median Ht(Diag) was -1.14 (p = 0.007) and Ht(PHV) was -0.79 (p = 0.039). Individually, 8/30 CD-M cases had one or more parameter affected: 2 boys had Ht(Diag )<-2, 3 boys had Ht(PHV) <-2, 2 boys had an Age(PHV) >2 years above population mean, and 2 boys had a PHV SDS <-2. In the whole group, Age(PHV) showed an association with erythrocyte sedimentation rate (r = 0.4; p = 0.005) and an inverse association with BMI (r = 0.4; p = 0.001).

CONCLUSION

Disorders of pubertal growth are more likely to occur in CD and, particularly, in boys.

摘要

背景

炎症性肠病（IBD）患者的青春期通常受到影响。

目的

确定克罗恩病（CD）和溃疡性结肠炎（UC）对青春期生长突增的影响。

方法

回顾性研究了 30 名男性 CD 患者（CD-M）、11 名女性 CD 患者（CD-F）、14 名男性 UC 患者（UC-M）和 12 名女性 UC 患者（UC-F）。通过计算身高峰值速度 SDS（PHV SDS）、诊断时身高 SDS（Ht(Diag)）和 PHV 时身高 SDS（Ht(PHV)）以及 PHV 年龄（Age(PHV)）来评估青春期生长情况。还收集了疾病活动的系统标志物。

结果

与正常人群相比，CD 组的青春期生长参数发生了改变：在 CD-M 组中，中位数 Ht(Diag)为-0.56（p=0.001），中位数 Age(PHV)为 14.45 岁（p=0.004），而在 CD-F 组中，中位数 Ht(Diag)为-1.14（p=0.007）和 Ht(PHV)为-0.79（p=0.039）。单独来看，30 例 CD-M 中有 8 例有一个或多个参数受到影响：2 例男孩 Ht(Diag)<-2，3 例男孩 Ht(PHV)<-2，2 例男孩 Age(PHV)高于人群平均值 2 岁以上，2 例男孩 PHV SDS<-2。在整个组中，Age(PHV)与红细胞沉降率（r=0.4；p=0.005）呈正相关，与 BMI 呈负相关（r=0.4；p=0.001）。