在药物发现和开发之间架起溶解度的桥梁。
Bridging solubility between drug discovery and development.
机构信息
Pharmacokinetics Dynamics and Metabolism, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
出版信息
Drug Discov Today. 2012 May;17(9-10):486-95. doi: 10.1016/j.drudis.2011.11.007. Epub 2011 Nov 26.
PMID:22138563
Abstract
Solubility has a crucial role in the success of a drug candidate. Compounds with low solubility not only cause problems for in vitro and in vivo assays, but also add significant burdens to drug development. Drug discovery and drug development often have different solubility screening requirements and methodologies have been developed to meet the needs of these different stages.
摘要
溶解度在候选药物的成功中起着至关重要的作用。溶解度低的化合物不仅会给体外和体内检测带来问题，而且会给药物开发带来巨大的负担。药物发现和药物开发通常有不同的溶解度筛选要求，已经开发了一些方法来满足这些不同阶段的需求。
Zotero 插件