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斯坦福同步辐射光源晶体学光束线的远程访问:用于培训、教育和合作的新工具。

Remote access to crystallography beamlines at SSRL: novel tools for training, education and collaboration.

作者信息

Smith Clyde A, Card Graeme L, Cohen Aina E, Doukov Tzanko I, Eriksson Thomas, Gonzalez Ana M, McPhillips Scott E, Dunten Pete W, Mathews Irimpan I, Song Jinhu, Soltis S Michael

机构信息

Stanford Synchrotron Radiation Lightsource, Menlo Park, CA 94025, USA.

出版信息

J Appl Crystallogr. 2010 Oct 1;43(Pt 5):1261-1270. doi: 10.1107/S0021889810024696. Epub 2010 Aug 3.

Abstract

For the past five years, the Structural Molecular Biology group at the Stanford Synchrotron Radiation Lightsource (SSRL) has provided general users of the facility with fully remote access to the macromolecular crystallography beamlines. This was made possible by implementing fully automated beamlines with a flexible control system and an intuitive user interface, and by the development of the robust and efficient Stanford automated mounting robotic sample-changing system. The ability to control a synchrotron beamline remotely from the comfort of the home laboratory has set a new paradigm for the collection of high-quality X-ray diffraction data and has fostered new collaborative research, whereby a number of remote users from different institutions can be connected at the same time to the SSRL beamlines. The use of remote access has revolutionized the way in which scientists interact with synchrotron beamlines and collect diffraction data, and has also triggered a shift in the way crystallography students are introduced to synchrotron data collection and trained in the best methods for collecting high-quality data. SSRL provides expert crystallographic and engineering staff, state-of-the-art crystallography beamlines, and a number of accessible tools to facilitate data collection and in-house remote training, and encourages the use of these facilities for education, training, outreach and collaborative research.

摘要

在过去五年中,斯坦福同步辐射光源(SSRL)的结构分子生物学团队为该设施的普通用户提供了对大分子晶体学光束线的完全远程访问。这得益于实现了具有灵活控制系统和直观用户界面的全自动光束线,以及开发了强大且高效的斯坦福自动安装机器人样品更换系统。能够在舒适的家庭实验室中远程控制同步辐射光束线,为高质量X射线衍射数据的收集树立了新的范例,并促进了新的合作研究,使得来自不同机构的众多远程用户能够同时连接到SSRL光束线。远程访问的使用彻底改变了科学家与同步辐射光束线交互以及收集衍射数据的方式,也引发了晶体学学生接触同步辐射数据收集并接受高质量数据收集最佳方法培训方式的转变。SSRL提供专业的晶体学和工程人员、最先进的晶体学光束线以及许多便于数据收集和内部远程培训的工具,并鼓励将这些设施用于教育、培训、推广和合作研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9477/3238386/ce58628c3645/j-43-01261-fig1.jpg

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