LTBP，不只是一个护送服务。
LTBPs, more than just an escort service.
机构信息
Department of Cell Biology, NYU Langone Medical Center, New York, New York 10016, USA.
出版信息
J Cell Biochem. 2012 Feb;113(2):410-8. doi: 10.1002/jcb.23385.
Abstract
Latent transforming growth factor beta (TGF-β) binding proteins (LTBPs) are large extracellular glycoproteins structurally similar to fibrillins. They perform intricate and important roles in the extracellular matrix (ECM) and perturbations of their function manifest as a wide range of diseases. LTBPs are major regulators of TGF-β bioavailability and action. In addition, LTBPs interact with other ECM proteins-from cytokines to large multi-factorial aggregates like microfibrils and elastic fibers, affecting their genesis, structure, and performance. In the present article, we review recent advancements in the field and relate the complex roles of LTBP in development and homeostasis.
摘要
潜伏转化生长因子β（TGF-β）结合蛋白（LTBPs）是结构上与原纤维蛋白相似的大型细胞外糖蛋白。它们在细胞外基质（ECM）中发挥着复杂而重要的作用，其功能的紊乱表现为多种疾病。LTBPs 是 TGF-β 生物利用度和作用的主要调节剂。此外，LTBPs 与细胞外基质蛋白相互作用——从细胞因子到像微纤维和弹性纤维这样的大型多因子聚集体，影响它们的发生、结构和性能。在本文中，我们回顾了该领域的最新进展，并阐述了 LTBP 在发育和稳态中的复杂作用。
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