体外脂肪酸甲酯的种子对致病真菌巴西副球孢子菌的抑菌活性。
In vitro antifungal activity of fatty acid methyl esters of the seeds of Annona cornifolia A.St.-Hil. (Annonaceae) against pathogenic fungus Paracoccidioides brasiliensis.
机构信息
Universidade Federal de São João Del-Rei, Divinópolis, MG, Brasil.
出版信息
Rev Soc Bras Med Trop. 2011 Nov-Dec;44(6):777-80. doi: 10.1590/s0037-86822011000600024.
INTRODUCTION
Fatty acids are abundant in vegetable oils. They are known to have antibacterial and antifungal properties.
METHODS
Antifungal susceptibility was evaluated by broth microdilution assay following CLSI (formerly the NCCLS) guidelines against 16 fungal strains of clinical interest.
RESULTS
In this work, fatty acid methyl esters (FAME) was able to inhibit 12 clinical strains of the pathogenic fungus Paracoccidioides brasiliensis and were also active in the bioautographic assay against Cladosporium sphaerospermum.
CONCLUSIONS
FAME was a more potent antifungal than trimethoprim-sulfamethoxazole against P. brasiliensis under the experimental conditions tested.
简介
脂肪酸在植物油中含量丰富。已知它们具有抗菌和抗真菌的特性。
方法
按照 CLSI（前身为 NCCLS）指南，通过肉汤微量稀释法评估抗真菌药敏性，针对 16 株临床相关真菌株进行检测。
结果
在这项工作中，脂肪酸甲酯（FAME）能够抑制 12 株致病性真菌巴西副球孢子菌的临床株，并且在针对枝孢菌属的生物自显影测定中也具有活性。
结论
在测试的实验条件下，与甲氧苄啶-磺胺甲恶唑相比，FAME 对巴西副球孢子菌的抗真菌作用更强。
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