[老年男性血清CXCL16升高与急性冠脉综合征严重程度的相关性]

[Correlation of elevated serum CXCL16 and severity of acute coronary syndromes in male elders].

作者信息

Zhuge Xin, Wang Li-li, Sun Ning, Zhang Yun

机构信息

Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2011 Dec 13;91(46):3271-4.

PMID:22333148

Abstract

OBJECTIVE

To examine the level of circulating soluble CXC-chemokine ligand 16 (CXCL16) in different types of coronary artery disease and its association with severity of disease.

METHODS

A total of 204 male elders, aged 60 - 92 years old, were recruited and divided into control group (n = 40), stable angina pectoris group (SAP, n = 80) and acute coronary syndrome group (ACS, n = 84). enzyme-linked immunosorbent assay (ELISA) was used to examine the concentration of serum soluble CXCL16.

RESULTS

As compared with the control (1.87 mg/L) and SAP groups (2.01 mg/L), CXCL16 level was significantly increased in ACS group (2.35 mg/L) P = (0.001, 0.026). Correlation analysis showed that CXCL16 was associated with age (r = 0.152, P = 0.038) and C-reactive protein (CRP) (r = 0.270, P < 0.001). When categorizing CXCL16 into quartiles, logistic analysis adjusted for age and CRP showed that the higher CXCL16 concentrations significantly increased the risk of ACS but not SAP. The odds ratio of group IV OR (95%CI) were 7.91(2.41 - 21.54) versus group I as reference in ACS.

CONCLUSION

The elevated level of circulating soluble CXCL16 is associated with severity of disease in male elder ACS patients.

摘要

目的

检测不同类型冠心病患者循环中可溶性CXC趋化因子配体16（CXCL16）水平，并探讨其与疾病严重程度的关系。

方法

选取204例年龄在60 - 92岁的男性老年人，分为对照组（n = 40）、稳定型心绞痛组（SAP，n = 80）和急性冠脉综合征组（ACS，n = 84）。采用酶联免疫吸附测定法（ELISA）检测血清可溶性CXCL16浓度。

结果

与对照组（1.87 mg/L）和SAP组（2.01 mg/L）相比，ACS组CXCL16水平显著升高（2.35 mg/L），P =（0.001，0.026）。相关性分析显示，CXCL16与年龄（r = 0.152，P = 0.038）及C反应蛋白（CRP）（r = 0.270，P < 0.001）相关。将CXCL16分为四分位数后，经年龄和CRP校正的逻辑分析显示，较高的CXCL16浓度显著增加ACS风险，但不增加SAP风险。在ACS中，以I组为参照，IV组的比值比OR（95%CI）为7.91（2.41 - 21.54）。