A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient.
作者信息
Ratajczak J, Kucia M, Mierzejewska K, Liu R, Kim C H, Natarajan N, Sharma V, Miller D M, Maciejewski J, Ratajczak M Z
出版信息
Leukemia. 2012 Jul;26(7):1722-5. doi: 10.1038/leu.2012.46. Epub 2012 Feb 20.
PMID:22343521
Abstract
摘要
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