中枢神经系统细胞外核苷酸的 P2 受体：P2X7 和 P2Y₂ 受体相互作用在神经炎症中的作用。
P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation.
机构信息
Department of Biochemistry, University of Missouri, 540E Life Sciences Center, 1201 Rollins Road, Columbia, MO 65211-7310, USA.
出版信息
Mol Neurobiol. 2012 Aug;46(1):96-113. doi: 10.1007/s12035-012-8263-z. Epub 2012 Apr 1.
Abstract
Extracellular nucleotides induce cellular responses in the central nervous system (CNS) through the activation of ionotropic P2X and metabotropic P2Y nucleotide receptors. Activation of these receptors regulates a wide range of physiological and pathological processes. In this review, we present an overview of the current literature regarding P2X and P2Y receptors in the CNS with a focus on the contribution of P2X7 and P2Y(2) receptor-mediated responses to neuroinflammatory and neuroprotective mechanisms.
摘要
细胞外核苷酸通过激活中枢神经系统 (CNS) 中的离子型 P2X 和代谢型 P2Y 核苷酸受体诱导细胞反应。这些受体的激活调节广泛的生理和病理过程。在这篇综述中，我们概述了关于 CNS 中 P2X 和 P2Y 受体的当前文献，重点介绍了 P2X7 和 P2Y(2)受体介导的反应对神经炎症和神经保护机制的贡献。
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