脑源性神经营养因子Val66Met多态性与首发精神分裂症临床特征的关联性研究
[Association study of brain-derived neurotrophic factor Val66Met polymorphism and clinical characteristics of first episode schizophrenia].
作者信息
Sun Meng-meng, Liu Lan-fen, Yang Li-min, Wang Yan, Cui Kai-yan, Wang Li-na, Li Cui-luan, Qiao Dong-dong, Wang Ru-zhan
机构信息
School of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Apr;29(2):155-8. doi: 10.3760/cma.j.issn.1003-9406.2012.02.008.
OBJECTIVE
To assess the association between brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population.
METHODS
Genotyping of BDNF Val66Met polymorphism was carried out for 135 schizophrenic patients and 483 healthy controls with TaqMan probe technology. The patients' psychotic symptoms were assessed using the positive and negative syndrome scale (PANSS).
RESULTS
A significant difference was found in genotype distribution and allelic frequency of the Val66Met polymorphism between the two groups (P< 0.01). In patients, Met homozygotes had a significantly higher score in anxiety/depression factor, cognitive factor and total score of PANSS than Val carriers.
CONCLUSION
BDNF gene Val66Met polymorphism is associated with the pathogenesis of schizophrenia. The Met/Met genotype of BDNF Val66Met variant may be a risk factor for symptoms in first episode schizophrenia patients.
目的
评估脑源性神经营养因子（BDNF）基因Val66Met多态性与中国汉族人群首发精神分裂症临床特征之间的关联。
方法
采用TaqMan探针技术对135例精神分裂症患者和483例健康对照者进行BDNF Val66Met多态性基因分型。使用阳性与阴性症状量表（PANSS）评估患者的精神症状。
结果
两组之间Val66Met多态性的基因型分布和等位基因频率存在显著差异（P<0.01）。在患者中，Met纯合子在焦虑/抑郁因子、认知因子和PANSS总分上的得分显著高于Val携带者。
结论
BDNF基因Val66Met多态性与精神分裂症的发病机制有关。BDNF Val66Met变异体的Met/Met基因型可能是首发精神分裂症患者症状的一个危险因素。
Zotero 插件