利用激酶抑制剂开发用于通过荧光显微镜对激酶进行成像的小分子工具。
Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy.
作者信息
Zhang Zijuan, Kwiatkowski Nicholas, Zeng Hong, Lim Sang Min, Gray Nathanael S, Zhang Wei, Yang Priscilla L
机构信息
Department of Chemistry, University of Massachusetts Boston, Boston, MA 02125, USA.
出版信息
Mol Biosyst. 2012 Oct;8(10):2523-6. doi: 10.1039/c2mb25099c.
Abstract
As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.
摘要
随着荧光显微镜作为研究生物系统工具的应用不断增加，对能够选择性检测目标蛋白的其他工具的需求也在增加。现有的经过充分表征的选择性激酶抑制剂可用于开发通过荧光显微镜对激酶进行成像的新型小分子探针。
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