印度尼西亚结核病合并艾滋病病毒感染患者中CD4 + T淋巴细胞计数与结核类型之间的相关性。
The correlation between CD4+ T-lymphocyte count and tuberculosis form in TB-HIV coinfected patients in Indonesia.
作者信息
Fredy Felix C, Liwang Frans, Kurniawan Rudy, Nasir Anna Uyainah
机构信息
Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo Hospital. Jl. Diponegoro no. 71, Jakarta Pusat 10430, Indonesia.
出版信息
Acta Med Indones. 2012 Apr;44(2):122-7.
AIM
to find whether there is a correlation between CD4+ count and TB form in TB-HIV Coinfected patients in Indonesia.
METHODS
this is a cross-sectional study of the TB-HIV patients at National HIV Center POKDISUS, Cipto Mangunkusumo Hospital in 2008-2011. We classified TB form as pulmonary TB, extrapulmonary TB, milliary TB, and combination form. The data were analyzed by Spearman and lambda correlation test. We also did partial correlation test to eliminate some counfounding factors, including demography and clinical characteristics, that had been determinated before.
RESULTS
there were 122 TB-HIV patients (aged median 31 [18-34], 80% male) included in this study. The most common TB form was pulmonary TB (71.2%), then extrapulmonary TB (7.4%), the combined type (18.9%), and milliary TB (2.5%). Median of CD4+ count was 40 cells/mL (IQR 17.5-100.6). There was a very weak correlation between CD4+ count and TB form in TB-HIV patients in Indonesia (r=0.185; p=0.042). The other factor that also showed a significant correlation to TB form is HIV staging (r=0.289; p=0.001). After adjusting those factors, we found an increase on correlation between CD4+ count and TB form (r=0.353; p=0.000).
CONCLUSION
there was a correlation between CD4+ count and TB form in TB-HIV patients in Indonesia, but in a very weak correlation.
目的
探究印度尼西亚结核病合并艾滋病病毒（TB-HIV）感染患者的CD4+细胞计数与结核类型之间是否存在相关性。
方法
这是一项对2008年至2011年期间在雅加达中央医院国家艾滋病中心POKDISUS接受治疗的TB-HIV患者进行的横断面研究。我们将结核类型分为肺结核、肺外结核、粟粒性结核和混合型。数据采用Spearman和lambda相关性检验进行分析。我们还进行了偏相关性检验，以消除一些先前确定的混杂因素，包括人口统计学和临床特征。
结果
本研究纳入了122例TB-HIV患者（年龄中位数为31岁[18-34岁]，80%为男性）。最常见的结核类型是肺结核（71.2%），其次是肺外结核（7.4%）、混合型（18.9%）和粟粒性结核（2.5%）。CD4+细胞计数的中位数为40个细胞/毫升（四分位间距为17.5-100.6）。在印度尼西亚的TB-HIV患者中，CD4+细胞计数与结核类型之间存在非常弱的相关性（r=0.185；p=0.042）。另一个与结核类型也显示出显著相关性的因素是HIV分期（r=0.289；p=0.001）。在调整这些因素后，我们发现CD4+细胞计数与结核类型之间的相关性有所增加（r=0.353；p=0.000）。
结论
在印度尼西亚的TB-HIV患者中，CD4+细胞计数与结核类型之间存在相关性，但相关性非常弱。
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