来源于船盔的 BACE 抑制性黄烷酮

BACE inhibitory flavanones from Balanophora involucrata Hook. f.

机构信息

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

出版信息

Fitoterapia. 2012 Dec;83(8):1386-90. doi: 10.1016/j.fitote.2012.08.002. Epub 2012 Aug 14.

DOI:10.1016/j.fitote.2012.08.002

PMID:22909424

Abstract

One new flavanone (S)-5,7,3',5'-tetrahydroxy-flavanone-7-O-(6″-galloyl)-β-D-glucopyranose (1), together with one known flavanone and four known dihydrochalcones were isolated from the ethyl acetate partitions from an alcoholic extract of the whole plant of Balanophora involucrata Hook. f. All of the compounds were characterized by spectroscopic methods. Their in vitro BACE inhibitory effects were evaluated. Compounds 1, 2, 4, and 5 were found to be a little more active than the positive control, although all of which are below 50% inhibition at 10μM.

摘要

从蛇菰科植物密花蛇菰全株的醇提乙酸乙酯部位分离得到一个新的黄烷酮（S）-5,7,3',5'-四羟基黄烷酮-7-O-(6″-没食子酰基)-β-D-吡喃葡萄糖苷（1），以及一个已知的黄烷酮和四个已知的二氢查耳酮。所有化合物均通过光谱方法进行了表征。并评估了它们在体外对 BACE 的抑制作用。结果发现，化合物 1、2、4 和 5 的活性均略高于阳性对照，尽管在 10μM 时它们的抑制率均低于 50%。