CYP17 和 CYP3A4 多态性与非洲裔男性前列腺癌。
Polymorphisms in CYP17 and CYP3A4 and prostate cancer in men of African descent.
机构信息
North Shore Long Island Jewish Health System, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.
出版信息
Prostate. 2013 May;73(6):668-76. doi: 10.1002/pros.22612. Epub 2012 Nov 5.
BACKGROUND
A meta and pooled analysis of published and unpublished case-control studies was performed to evaluate the association of CYP17 (rs743572) and CYP3A4 (rs2740574) polymorphisms and prostate cancer (PCa) in men from the USA, Caribbean, and Africa.
METHODS
Eight publications (seven studies) and two unpublished studies for CYP17 included 1,580 subjects (559 cases and 1,021 controls) and eleven publications and three unpublished studies for CYP3A4 included 3,400 subjects (1,429 cases and 1,971 controls).
RESULTS
Overall, the CYP17 heterozygous and homozygous variants were not associated with PCa, but they confer a 60% increased risk of PCa in a sub-group analysis restricted to African-American men (T/C + C/C, OR: 1.6, 95% CI: 1.1-2.4). No associations were observed for CYP3A4, overall and in stratified analyses for African-Americans and Africans. The pooled analysis suggests that after adjusting for study, age, PSA, and family history of PCa, CYP17 was associated with PCa for men of African ancestry (Adjusted OR: 3.5, 95% CI: 1.2-10.0).
CONCLUSIONS
Our findings suggest that genetic factors involved in the androgen pathway play a role in PCa risk among men of African ancestry.
背景
对已发表和未发表的病例对照研究进行了荟萃分析和汇总分析，以评估 CYP17（rs743572）和 CYP3A4（rs2740574）多态性与来自美国、加勒比和非洲的男性前列腺癌（PCa）之间的关联。
方法
八项出版物（七项研究）和两项关于 CYP17 的未发表研究包括 1580 名受试者（559 例病例和 1021 名对照），十一项出版物和三项关于 CYP3A4 的未发表研究包括 3400 名受试者（1429 例病例和 1971 名对照）。
结果
总体而言，CYP17 杂合和纯合变体与 PCa 无关，但在仅限于非裔美国男性的亚组分析中，它们使 PCa 的风险增加了 60%（T/C+C/C，OR：1.6，95%CI：1.1-2.4）。对于 CYP3A4，总体以及对非裔美国人和非洲人的分层分析均未观察到相关性。汇总分析表明，在调整了研究、年龄、PSA 和 PCa 家族史后，CYP17 与非洲裔男性的 PCa 相关（调整后的 OR：3.5，95%CI：1.2-10.0）。
结论
我们的研究结果表明，雄激素途径中涉及的遗传因素在非洲裔男性的 PCa 风险中起作用。
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