社交隔离小鼠前额叶皮质的成年髓鞘形成受损。
Impaired adult myelination in the prefrontal cortex of socially isolated mice.
机构信息
Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA.
出版信息
Nat Neurosci. 2012 Dec;15(12):1621-3. doi: 10.1038/nn.3263. Epub 2012 Nov 11.
Abstract
Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.
摘要
长期的成年老鼠社交隔离会导致前额叶皮层（PFC）少突胶质细胞的行为、转录和超微结构改变，并损害成年髓鞘形成。社交再融入足以使行为和转录变化正常化。短期隔离会影响染色质和髓鞘，但不会引起行为变化。因此，成年 PFC 中的髓鞘形成少突胶质细胞会对社交互动做出反应，导致染色质改变，表明髓鞘形成是一种成年期可塑性的形式。
相似文献
1
Impaired adult myelination in the prefrontal cortex of socially isolated mice.
Nat Neurosci. 2012 Dec;15(12):1621-3. doi: 10.1038/nn.3263. Epub 2012 Nov 11.
2
Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice.
J Neurosci. 2016 Jan 20;36(3):957-62. doi: 10.1523/JNEUROSCI.3608-15.2016.
3
Axonal plasticity elicits long-term changes in oligodendroglia and myelinated fibers.
Glia. 2010 Jan 1;58(1):29-42. doi: 10.1002/glia.20897.
4
Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function.
Sci Rep. 2017 Jul 14;7(1):5481. doi: 10.1038/s41598-017-05632-2.
5
Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene.
J Neurosci. 2005 Jul 27;25(30):7004-13. doi: 10.1523/JNEUROSCI.0288-05.2005.
6
Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP-1-deficient mice.
J Neurosci Res. 2004 Jul 1;77(1):15-25. doi: 10.1002/jnr.20155.
7
The role of oligodendrocyte pathology in schizophrenia.
Int J Neuropsychopharmacol. 2007 Aug;10(4):537-45. doi: 10.1017/S1461145707007626. Epub 2007 Feb 21.
8
Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development.
Glia. 2002 Jan;37(1):19-30. doi: 10.1002/glia.10014.
9
Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination.
Ann Neurol. 2010 Nov;68(5):703-16. doi: 10.1002/ana.22090.
10
Ultrastructural study on myelination in rat spinal cord during the early postnatal stage.
Brain Dev. 1980;2(4):337-43. doi: 10.1016/s0387-7604(80)80045-3.
引用本文的文献
1
Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses.
Neurosci Bull. 2025 Jul 17. doi: 10.1007/s12264-025-01452-x.
2
Cortical and white matter T1w/T2w development proceed in concert during early infancy.
bioRxiv. 2025 Jul 10:2025.07.07.663449. doi: 10.1101/2025.07.07.663449.
3
Discovery of oligodendrocyte enhancers that regulate Sox10 expression.
PLoS Genet. 2025 Jul 11;21(7):e1011778. doi: 10.1371/journal.pgen.1011778. eCollection 2025 Jul.
4
A Meta-Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long-Term Downregulation of Myelin-Related Gene Expression.
Brain Behav. 2025 Jun;15(6):e70608. doi: 10.1002/brb3.70608.
5
Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities.
Mol Neurodegener. 2025 Jun 15;20(1):69. doi: 10.1186/s13024-025-00861-w.
6
The relationship between neurodevelopmental disorders (NDDs) and NLRP3 inflammasome.
Inflamm Res. 2025 Jun 3;74(1):90. doi: 10.1007/s00011-025-02052-1.
7
Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy.
Genes (Basel). 2025 May 17;16(5):590. doi: 10.3390/genes16050590.
8
The potential of repurposing clemastine to promote remyelination.
Front Cell Neurosci. 2025 May 7;19:1582902. doi: 10.3389/fncel.2025.1582902. eCollection 2025.
9
Activity-driven myelin sheath growth is mediated by mGluR5.
Nat Neurosci. 2025 May 14. doi: 10.1038/s41593-025-01956-9.
10
Prefrontal cortex excitatory neurons show distinct response to heroin-associated cue and social stimulus after prolonged heroin abstinence in mice.
Neuropsychopharmacology. 2025 Apr 13. doi: 10.1038/s41386-025-02102-6.
本文引用的文献
1
A critical period for social experience-dependent oligodendrocyte maturation and myelination.
Science. 2012 Sep 14;337(6100):1357-60. doi: 10.1126/science.1220845.
2
A systematic review of diffusion tensor imaging studies in affective disorders.
Biol Psychiatry. 2009 Nov 1;66(9):814-23. doi: 10.1016/j.biopsych.2009.05.024. Epub 2009 Jul 17.
3
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.
Nat Neurosci. 2009 Jul;12(7):829-38. doi: 10.1038/nn.2333. Epub 2009 Jun 7.
4
Adult CST-null mice maintain an increased number of oligodendrocytes.
J Neurosci Res. 2009 Nov 15;87(15):3403-14. doi: 10.1002/jnr.22003.
5
Spatiotemporal ablation of myelinating glia-specific neurofascin (Nfasc NF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains.
J Neurosci Res. 2009 Jun;87(8):1773-93. doi: 10.1002/jnr.22015.
6
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.
Nat Neurosci. 2008 Sep;11(9):1024-34. doi: 10.1038/nn.2172.
7
CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits.
Nat Neurosci. 2009 Feb;12(2):200-9. doi: 10.1038/nn.2257. Epub 2009 Jan 18.
8
Depression in multiple sclerosis: review and theoretical proposal.
J Int Neuropsychol Soc. 2008 Sep;14(5):691-724. doi: 10.1017/S1355617708081174.
9
White matter in learning, cognition and psychiatric disorders.
Trends Neurosci. 2008 Jul;31(7):361-70. doi: 10.1016/j.tins.2008.04.001. Epub 2008 Jun 5.
10
The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation.
Neuron. 2007 Jul 19;55(2):217-30. doi: 10.1016/j.neuron.2007.06.029.
Zotero 插件