癌症中的能量代谢改变：治疗干预的独特机会。
Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention.
机构信息
Department of Pharmacology, College of Pharmaceutical Sciences; Soochow University, Jiangsu, China.
出版信息
Cancer Biol Ther. 2013 Feb;14(2):81-9. doi: 10.4161/cbt.22958. Epub 2012 Nov 28.
Abstract
The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.
摘要
奥托·瓦尔堡（Otto Warburg）博士的早期观察结果表明，恶性肿瘤细胞与相邻正常细胞之间在代谢方面存在根本差异。许多研究进一步报告了细胞代谢改变与治疗结果之间的关系。这些观察结果表明，针对癌症中独特的代谢途径可能是癌症治疗的有效策略。近年来，人们对改变细胞代谢如何促进肿瘤存活和生长的机制进行了加速研究。本文重点介绍了癌症中代谢改变的当前概念，以及糖酵解、线粒体和谷氨酰胺代谢中涉及的分子靶点，并讨论了基于细胞代谢的癌症治疗的未来展望。
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