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老年患者后路翻修手术治疗症状性假关节、邻近节段病或同节段复发性狭窄。第 1 部分。两年结果和临床疗效:临床文章。

Revision lumbar surgery in elderly patients with symptomatic pseudarthrosis, adjacent-segment disease, or same-level recurrent stenosis. Part 1. Two-year outcomes and clinical efficacy: clinical article.

机构信息

Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

出版信息

J Neurosurg Spine. 2013 Feb;18(2):139-46. doi: 10.3171/2012.11.SPINE12224. Epub 2012 Dec 11.

Abstract

OBJECT

Same-level recurrent lumbar stenosis, pseudarthrosis, and adjacent-segment disease (ASD) are potential complications that can occur after index lumbar spine surgery, leading to significant discomfort and radicular pain. While numerous studies have demonstrated excellent results following index lumbar spine surgery in elderly patients (age > 65 years), the effectiveness of revision lumbar surgery in this cohort remains unclear. The aim of this study was to assess the long-term effectiveness of revision lumbar decompression and fusion in the treatment of symptomatic pseudarthrosis, ASD, and same-level recurrent stenosis, using validated patient-reported outcomes.

METHODS

After a review of the institutional database, 69 patients who had undergone revision neural decompression and instrumented fusion for ASD (28 patients), pseudarthrosis (17 patients), or same-level recurrent stenosis (24 patients) were included in this study. Baseline and 2-year scores on the visual analog scale for leg pain (VAS-LP), VAS for back pain (VAS-BP), Oswestry Disability Index (ODI), and Zung Self-Rating Depression Scale (SDS) as well as the time to narcotic independence, time to return to baseline activity level, health state utility (EQ-5D, the EuroQol-5D health survey), and physical and mental component summary scores of the 12-Item Short-Form Health Survey (SF-12 PCS and MCS) were assessed.

RESULTS

Compared with the preoperative status, VAS-BP was significantly improved 2 years after surgery for ASD (mean ± standard deviation 9 ± 2 vs 4.01 ± 2.56, p = 0.001), pseudarthrosis (7.41 ± 1 vs 5.52 ± 3.08, p = 0.02), and same-level recurrent stenosis (7 ± 2.00 vs 5.00 ± 2.34, p = 0.003). The 2-year ODI was also significantly improved after surgery for ASD (29 ± 9 vs 23.10 ± 10.18, p = 0.001), pseudarthrosis (28.47 ± 5.85 vs 24.41 ± 7.75, p = 0.001), and same-level recurrent stenosis (30.83 ± 5.28 vs 26.29 ± 4.10, p = 0.003). The Zung SDS score and SF-12 MCS did not change appreciably after surgery in any of the cohorts, with an overall mean 2-year change of 1.01 ± 5.32 (p = 0.46) and 2.02 ± 9.25 (p = 0.22), respectively.

CONCLUSIONS

Data in this study suggest that revision lumbar decompression and extension of fusion for symptomatic pseudarthrosis, ASD, and same-level recurrent stenosis provides improvement in low-back pain, disability, and quality of life and should be considered a viable treatment option for elderly patients with persistent or recurrent back and radicular pain. Mental health symptoms may be more refractory to revision surgery.

摘要

目的

同节段腰椎狭窄症、假关节形成和邻近节段疾病(ASD)是指数腰椎手术后可能出现的潜在并发症,导致明显的不适和神经根痛。虽然大量研究表明,老年患者(年龄>65 岁)指数腰椎手术后效果良好,但这一人群的翻修腰椎手术效果仍不清楚。本研究旨在评估使用经过验证的患者报告结果,对有症状的假关节形成、ASD 和同节段复发性狭窄进行翻修腰椎减压和融合的长期疗效。

方法

在对机构数据库进行审查后,纳入了 69 例因 ASD(28 例)、假关节形成(17 例)或同节段复发性狭窄(24 例)而行翻修神经减压和器械融合的患者。评估基线和术后 2 年时的腿痛视觉模拟量表(VAS-LP)、腰痛视觉模拟量表(VAS-BP)、Oswestry 残疾指数(ODI)、Zung 抑郁自评量表(SDS)评分,以及阿片类药物依赖时间、恢复基线活动水平时间、健康状态效用(EQ-5D,欧洲五维健康量表)、12 项简明健康调查(SF-12 PCS 和 MCS)的身体和精神成分综合评分。

结果

与术前相比,ASD 患者术后 2 年时的 VAS-BP 显著改善(平均±标准差 9±2 与 4.01±2.56,p=0.001),假关节形成患者(7.41±1 与 5.52±3.08,p=0.02)和同节段复发性狭窄患者(7±2.00 与 5.00±2.34,p=0.003)也如此。ASD 患者术后 2 年时的 ODI 也显著改善(29±9 与 23.10±10.18,p=0.001),假关节形成患者(28.47±5.85 与 24.41±7.75,p=0.001)和同节段复发性狭窄患者(30.83±5.28 与 26.29±4.10,p=0.003)也如此。术后各队列的 Zung SDS 评分和 SF-12 MCS 均无明显变化,总体平均 2 年变化分别为 1.01±5.32(p=0.46)和 2.02±9.25(p=0.22)。

结论

本研究数据表明,对有症状的假关节形成、ASD 和同节段复发性狭窄进行翻修腰椎减压和融合术,可改善下腰痛、残疾和生活质量,应被视为老年患者持续或复发性腰腿痛的一种可行治疗选择。精神健康症状可能对翻修手术更具抵抗力。

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