[Antidepressant pharmacokinetics during pregnancy].

The influence of pregnancy state on the cytochrome P-450 dependent bioconversion and pharmacokinetics of antidepressants has been studied. Specific features of the bioconversion of some antidepressants are determined. Results of pharmacokinetic investigations based on the dynamics of antidepressant concentration in the blood plasma of pregnant women are considered. The necessity of changing the daily dose of antidepressants during pregnancy is discussed. Data on the ratio of the plasma concentration of antidepressants in a newborn to that in the mother and on the role of transporter proteins in the transplacentar transfer of antidepressant drugs are presented.