光学相干断层扫描测量的视网膜神经纤维层厚度与视神经萎缩视野参数之间的相关性
Correlation between Retinal Nerve Fiber Layer Thickness by Optical Coherence Tomography and Perimetric Parameters in Optic Atrophy.
作者信息
Soltan-Sanjari Mostafa, Parvaresh Mohammad-Mehdi, Maleki Arash, Ghasemi-Falavarjani Khalil, Bakhtiari Pejman
机构信息
Ophthalmic Research Center, Rasoul Akram Hospital, Iran Medical University, Tehran, Iran.
出版信息
J Ophthalmic Vis Res. 2008 Apr;3(2):91-4.
PURPOSE
To investigate the correlation between retinal nerve fiber layer (RNFL) thickness determined by optical coherence tomography (OCT) and visual field (VF) parameters in patients with optic atrophy.
METHODS
This study was performed on 35 eyes of 28 patients with optic atrophy. RNFL thickness was measured by OCT (Carl Zeiss, Jena, Germany) and automated perimetry was performed using the Humphrey Field Analyzer (Carl Zeiss, Jena, Germany). The correlation between RNFL thickness and VF parameters was evaluated.
RESULTS
Mean global RNFL thickness was 44.9±27.5 μm which was significantly correlated with mean deviation score on automated perimetry (r=0.493, P=0.003); however, no significant correlation was observed between visual field pattern standard deviation and the corresponding quadrantic RNFL thickness. In a similar manner, no significant association was found between visual acuity and RNLF thickness.
CONCLUSION
Mean global RNFL thickness as determined by OCT seems to be correlated with VF defect depth as represented by the mean deviation score on Humphrey VF testing. OCT may be used as an objective diagnostic tool in the evaluation of patients with optic atrophy.
目的
研究光学相干断层扫描（OCT）测定的视网膜神经纤维层（RNFL）厚度与视神经萎缩患者视野（VF）参数之间的相关性。
方法
对28例视神经萎缩患者的35只眼进行研究。使用OCT（德国耶拿卡尔蔡司公司）测量RNFL厚度，并使用Humphrey视野分析仪（德国耶拿卡尔蔡司公司）进行自动视野检查。评估RNFL厚度与VF参数之间的相关性。
结果
平均整体RNFL厚度为44.9±27.5μm，与自动视野检查的平均偏差得分显著相关（r = 0.493，P = 0.003）；然而，视野模式标准差与相应象限的RNFL厚度之间未观察到显著相关性。同样，视力与RNLF厚度之间也未发现显著关联。
结论
OCT测定的平均整体RNFL厚度似乎与Humphrey视野测试中平均偏差得分所代表的VF缺损深度相关。OCT可作为评估视神经萎缩患者的客观诊断工具。
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