可见光驱动光氧化还原催化的烯烃分子间氨基三氟甲基化反应。
Intermolecular aminotrifluoromethylation of alkenes by visible-light-driven photoredox catalysis.
机构信息
Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan.
出版信息
Org Lett. 2013 May 3;15(9):2136-9. doi: 10.1021/ol4006272. Epub 2013 Apr 19.
PMID:23600821
Abstract
Intermolecular aminotrifluoromethylation of alkenes catalyzed by Ru(bpy)3 under visible light irradiation has been explored. The present photocatalytic protocol achieves highly efficient and regioselective difunctionalization of C═C bonds, leading to a variety of β-trifluoromethylamines. The reaction is applied to "late-stage aminotrifluoromethylation" of steroid and amino acid scaffolds.
摘要
可见光照射下 Ru(bpy)3 催化的烯烃分子间氨三氟甲基化反应得到了研究。本光催化方法实现了 C═C 键的高效和区域选择性双官能化，得到了多种 β-三氟甲基胺。该反应可应用于甾体和氨基酸支架的“后期氨三氟甲基化”。
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