对呋喃妥因或美西林耐药的大肠埃希菌具有较高的遗传多样性，表明其克隆传播的倾向较低。
High genetic diversity of nitrofurantoin- or mecillinam-resistant Escherichia coli indicates low propensity for clonal spread.
机构信息
Department of Clinical Microbiology, Central Hospital, SE-351 85 Växjö, Sweden.
出版信息
J Antimicrob Chemother. 2013 Sep;68(9):1974-7. doi: 10.1093/jac/dkt159. Epub 2013 May 2.
OBJECTIVES
The empirical treatment with trimethoprim or ciprofloxacin of urinary tract infections (UTIs) is now questioned, partly due to the global expansion of a few resistant clonal groups of Escherichia coli.
METHODS
In this study we investigated the clonal structure of 34 strains of E. coli (collected from non-pregnant women aged 18-65 years with uncomplicated UTIs in Europe and Canada) resistant to either of two other common treatment alternatives for uncomplicated UTIs, mecillinam or nitrofurantoin, using multilocus sequence typing (MLST).
RESULT
The 34 isolates were, despite high levels of multiresistance, distributed all over the E. coli genetic diversity spectrum with little association of antibiotic resistance to specific clonal groups.
CONCLUSIONS
The results of this study indicate a low probability of a future clonal spread of resistance to mecillinam and nitrofurantoin.
目的
由于少数具有耐药性的大肠杆菌克隆群在全球范围内的扩张，目前人们对尿路感染（UTIs）的经验性治疗（即用甲氧苄啶或环丙沙星进行治疗）提出了质疑。
方法
在这项研究中，我们使用多位点序列分型（MLST）技术，对 34 株来自欧洲和加拿大的年龄在 18-65 岁之间、患有单纯性尿路感染的未怀孕女性的大肠杆菌菌株（这些菌株对两种常用于治疗单纯性尿路感染的其他替代药物，即美西林或呋喃妥因具有耐药性）的克隆结构进行了研究。
结果
尽管这些分离株具有高度的多重耐药性，但它们分布在整个大肠杆菌遗传多样性谱中，抗生素耐药性与特定的克隆群之间几乎没有关联。
结论
本研究结果表明，对美西林和呋喃妥因的耐药性不太可能在未来出现克隆传播。
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