RB 进入线粒体。
RB goes mitochondrial.
机构信息
Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA.
出版信息
Genes Dev. 2013 May 1;27(9):975-9. doi: 10.1101/gad.219451.113.
Abstract
The retinoblastoma tumor suppressor RB is well known for its capacity to restrict cell cycle progression at the G1/S transition of the cell cycle by controlling the transcription of cell cycle genes. In this issue of Genes & Development, Hilgendorf and colleagues (pp. 1003-1015) have identified a novel tumor suppressor function for RB independent of its role as a transcriptional regulator, in which RB directly activates the apoptosis regulator Bax at the mitochondria to promote cell death.
摘要
视网膜母细胞瘤肿瘤抑制因子 RB 通过控制细胞周期基因的转录，以其在细胞周期 G1/S 转换时限制细胞周期进程的能力而闻名。在本期《基因与发育》中，Hilgendorf 及其同事（第 1003-1015 页）发现了 RB 的一种新的肿瘤抑制功能，这种功能与作为转录调节剂的作用无关，其中 RB 直接在线粒体上激活凋亡调节剂 Bax，以促进细胞死亡。
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