血清脂质与年龄相关性黄斑变性之间的相关性：一项病例对照研究。
Correlation between serum lipids and age-related macular degeneration: a case-control study.
作者信息
Davari Mohammad Hossein, Gheitasi Hoda, Yaghobi Gholamhossein, Heydari Behrouz
机构信息
Birjand Atherosclerosis and Coronary Artery Research Centre, Department of Ophthalmology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
出版信息
J Res Health Sci. 2013 May 29;13(1):98-101.
BACKGROUND
Age-related macular degeneration (AMD) is one of the leading causes of visual loss among people aged 65 yr and older. The pathophysiology of AMD is poorly understood. The purpose of this study was to evaluate the relationship between serum lipid concentrations and age-related macular degeneration.
METHODS
In this case-control study, total cholesterol (TCH), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) of 32 patients with AMD were compared with 32 subjects without AMD that were matched for age. Data were analyzed using Independent t and Chi-Square Tests.
RESULTS
TCH, LDL, and TG serum concentrations were significantly higher in AMD patients compared with control group (P<0.001, P<0.001 and P<0.017 respectively). There was no difference in HDL concentration between two groups (P=0.781).
CONCLUSION
High level of total cholesterol, TG and LDL were associated with increased risk of AMD. Results of this study suggest further research to better understand the underlying biological mechanisms of AMD related to serum cholesterol.
背景
年龄相关性黄斑变性（AMD）是65岁及以上人群视力丧失的主要原因之一。AMD的病理生理学尚不清楚。本研究的目的是评估血清脂质浓度与年龄相关性黄斑变性之间的关系。
方法
在这项病例对照研究中，将32例AMD患者的总胆固醇（TCH）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和甘油三酯（TG）与32例年龄匹配的非AMD受试者进行比较。使用独立t检验和卡方检验分析数据。
结果
与对照组相比，AMD患者的TCH、LDL和TG血清浓度显著更高（分别为P<0.001、P<0.001和P<0.017）。两组之间的HDL浓度没有差异（P=0.781）。
结论
总胆固醇、TG和LDL水平升高与AMD风险增加相关。本研究结果表明需要进一步研究，以更好地了解与血清胆固醇相关的AMD潜在生物学机制。
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