端粒酶在癌症与衰老的交汇点。
Telomerase at the intersection of cancer and aging.
机构信息
Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, E-28029, Spain.
出版信息
Trends Genet. 2013 Sep;29(9):513-20. doi: 10.1016/j.tig.2013.06.007. Epub 2013 Jul 19.
Although cancer and aging have been studied as independent diseases, mounting evidence suggests that cancer is an aging-associated disease and that cancer and aging share many molecular pathways. In particular, recent studies validated telomerase activation as a potential therapeutic target for age-related diseases; in addition, abnormal telomerase expression and telomerase mutations have been associated with many different types of human tumor. Here, we revisit the connection between telomerase and cancer and aging in light of recent findings supporting a role for telomerase not only in telomere elongation, but also in metabolic fitness and Wnt activation. Understanding the physiological impact of telomerase regulation is fundamental given the therapeutic strategies that are being developed that involve telomerase modulation.
虽然癌症和衰老已被作为独立的疾病进行研究，但越来越多的证据表明癌症是一种与衰老相关的疾病，癌症和衰老有许多共同的分子途径。特别是，最近的研究证实端粒酶激活是治疗与年龄相关疾病的一个有潜力的靶点；此外，异常的端粒酶表达和端粒酶突变与许多不同类型的人类肿瘤有关。在这里，我们根据最近的发现重新审视端粒酶与癌症和衰老之间的联系，这些发现支持端粒酶的作用不仅在于端粒的延长，还在于代谢适应和 Wnt 的激活。鉴于正在开发涉及端粒酶调节的治疗策略，了解端粒酶调节的生理影响是至关重要的。
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