控制 G1 期和 S 期细胞周期转录。
Control of cell cycle transcription during G1 and S phases.
机构信息
Medical Research Council (MRC) Laboratory for Molecular Cell Biology, University College London, London, UK.
出版信息
Nat Rev Mol Cell Biol. 2013 Aug;14(8):518-28. doi: 10.1038/nrm3629.
Abstract
The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition. CDK activation initiates a positive feedback loop that further increases CDK activity, and this commits the cell to division by inducing genome-wide transcriptional changes. G1-S transcripts encode proteins that regulate downstream cell cycle events. Recent work is beginning to reveal the complex molecular mechanisms that control the temporal order of transcriptional activation and inactivation, determine distinct functional subgroups of genes and link cell cycle-dependent transcription to DNA replication stress in yeast and mammals.
摘要
细胞周期 G1 期向 S 期的准确转换对于控制真核细胞增殖至关重要，其调控失常会促进肿瘤发生。在 G1 期，依赖于生长的细胞周期蛋白依赖性激酶（CDK）活性促进 DNA 复制并启动 G1 期向 S 期的转变。CDK 的激活引发正反馈环，进一步增加 CDK 的活性，通过诱导全基因组转录变化使细胞进入分裂状态。G1-S 转录物编码调节下游细胞周期事件的蛋白质。最近的研究工作开始揭示控制转录激活和失活的时间顺序、确定基因的不同功能亚群以及将细胞周期依赖性转录与酵母和哺乳动物中 DNA 复制应激联系起来的复杂分子机制。
相似文献
1
Control of cell cycle transcription during G1 and S phases.
Nat Rev Mol Cell Biol. 2013 Aug;14(8):518-28. doi: 10.1038/nrm3629.
2
The Temporal Regulation of S Phase Proteins During G.
Adv Exp Med Biol. 2017;1042:335-369. doi: 10.1007/978-981-10-6955-0_16.
3
Control of the G1/S transition.
Cancer Surv. 1997;29:7-23.
4
lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans.
Development. 2001 Nov;128(21):4349-59. doi: 10.1242/dev.128.21.4349.
5
[Molecular mechanisms controlling the cell cycle: fundamental aspects and implications for oncology].
Cancer Radiother. 2001 Apr;5(2):109-29. doi: 10.1016/s1278-3218(01)00087-7.
6
[Ubiquitin system regulating G1 and S phases of cell cycle].
Tanpakushitsu Kakusan Koso. 2006 Aug;51(10 Suppl):1362-9.
7
Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast.
Nat Cell Biol. 2004 Jan;6(1):59-66. doi: 10.1038/ncb1078. Epub 2003 Dec 14.
8
Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators.
Nat Cell Biol. 2000 Apr;2(4):232-9. doi: 10.1038/35008660.
9
G(1) to S transition: more than a cell cycle engine switch.
Curr Opin Plant Biol. 2002 Dec;5(6):480-6. doi: 10.1016/s1369-5266(02)00301-1.
10
Phosphorylation of retinoblastoma-related protein by the cyclin D/cyclin-dependent kinase complex is activated at the G1/S-phase transition in tobacco.
Plant Cell. 2002 Aug;14(8):1847-57. doi: 10.1105/tpc.002550.
引用本文的文献
1
Comprehensive profiling of RNA modification-related genes identifies RNA mG binding protein CBP20 as a therapeutic target for tumor growth inhibition.
Exp Mol Med. 2025 Sep 1. doi: 10.1038/s12276-025-01531-z.
2
Nrm1 is a bistable switch connecting cell cycle progression to transcriptional control.
EMBO Rep. 2025 Aug 29. doi: 10.1038/s44319-025-00566-7.
3
A novel chromen-based small molecule induces apoptosis and modulates cellular response to triple-negative breast cancer.
Sci Rep. 2025 Aug 29;15(1):31914. doi: 10.1038/s41598-025-16195-y.
4
Research progress on NAT10-mediated acetylation in normal development and disease.
Front Cell Dev Biol. 2025 Aug 13;13:1623276. doi: 10.3389/fcell.2025.1623276. eCollection 2025.
5
From "Traditional" to "Trained" Immunity: Exploring the Novel Frontiers of Immunopathogenesis in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Biomedicines. 2025 Aug 18;13(8):2004. doi: 10.3390/biomedicines13082004.
6
The cAMP-PKA signaling initiates mitosis by phosphorylating Bora.
Nat Commun. 2025 Aug 24;16(1):7898. doi: 10.1038/s41467-025-63352-y.
7
CDK12 inhibition enhances oxaliplatin efficacy in gastric cancer by suppressing the MAPK signaling pathway.
J Gastrointest Oncol. 2025 Jun 30;16(3):823-839. doi: 10.21037/jgo-2025-392. Epub 2025 Jun 23.
8
Comprehensive Phytochemical Analysis and Evaluation of Antioxidant, Antimicrobial, Cytotoxic, and Immunomodulatory Activities of Commercial Cinnamon Bark Essential Oil ( L.).
Int J Mol Sci. 2025 Jul 5;26(13):6482. doi: 10.3390/ijms26136482.
9
Hallmarks of cellular senescence: biology, mechanisms, regulations.
Exp Mol Med. 2025 Jul 10. doi: 10.1038/s12276-025-01480-7.
10
PPP1R12B inhibits cell proliferation by inducing G0/G1 phase arrest via PAK2/β-catenin axis in hepatocellular carcinoma.
Front Cell Dev Biol. 2025 Jun 19;13:1621705. doi: 10.3389/fcell.2025.1621705. eCollection 2025.
本文引用的文献
1
Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription.
Curr Biol. 2013 Sep 9;23(17):1629-37. doi: 10.1016/j.cub.2013.06.063. Epub 2013 Aug 15.
2
Identification of preferentially reactivated genes during early G1 phase using nascent mRNA as an index of transcriptional activity.
Biochem Biophys Res Commun. 2013 Jan 18;430(3):1005-10. doi: 10.1016/j.bbrc.2012.12.048. Epub 2012 Dec 19.
3
E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.
EMBO J. 2012 Oct 3;31(19):3871-84. doi: 10.1038/emboj.2012.231. Epub 2012 Aug 17.
4
The checkpoint transcriptional response: make sure to turn it off once you are satisfied.
Cell Cycle. 2012 Sep 1;11(17):3166-74. doi: 10.4161/cc.21197. Epub 2012 Aug 16.
5
Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6042-7. doi: 10.1073/pnas.1203734109. Epub 2012 Apr 2.
6
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle.
Cell Div. 2012 Mar 14;7(1):10. doi: 10.1186/1747-1028-7-10.
7
DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1.
EMBO J. 2012 Apr 4;31(7):1811-22. doi: 10.1038/emboj.2012.28. Epub 2012 Feb 14.
8
Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes.
EMBO J. 2012 Apr 4;31(7):1798-810. doi: 10.1038/emboj.2012.27. Epub 2012 Feb 14.
9
E2F7 represses a network of oscillating cell cycle genes to control S-phase progression.
Nucleic Acids Res. 2012 Apr;40(8):3511-23. doi: 10.1093/nar/gkr1203. Epub 2011 Dec 17.
10
Evolution of networks and sequences in eukaryotic cell cycle control.
Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27;366(1584):3532-44. doi: 10.1098/rstb.2011.0078.
Zotero 插件