临床采集样本中汗氯、钠与年龄的关系。
Relationship between sweat chloride, sodium, and age in clinically obtained samples.
机构信息
New York Medical College, Department of Pediatrics, Division of Pediatric Pulmonology, Allergy, and Sleep Medicine Munger Pavilion Room 106, Valhalla, NY 10595, United States; The Armond V. Mascia, MD Cystic Fibrosis Center of the Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, United States.
New York Medical College, Department of Epidemiology and Community Health, School of Health Sciences and Practice, Valhalla, NY 10595, United States.
出版信息
J Cyst Fibros. 2014 Jan;13(1):10-4. doi: 10.1016/j.jcf.2013.07.003. Epub 2013 Aug 2.
BACKGROUND
The relationship between sweat electrolytes and age is uncertain, as is the value of measuring sodium or the chloride:sodium ratio.
METHODS
13,785 sweat tests performed over 23 years at one center through the Macroduct collection in clinically obtained samples were analyzed.
RESULTS
Sweat chloride tended to decrease over the first year of life, slowly increase until the fourth decade, then either level off or slightly decrease. In children, sweat sodium overlapped between those with positive and negative sweat tests, but not in adults. If the sweat test was positive, there was a higher likelihood of having a chloride:sodium ratio >1, but most subjects with a ratio >1 did not have CF.
CONCLUSIONS
Sweat chloride and sodium vary with age. Measurement of sweat sodium did not add discriminatory value. The proportion of subjects with a chloride:sodium ratio >1, with or without CF, varied greatly between age ranges.
背景
汗液电解质与年龄的关系尚不确定，测量钠或氯/钠比值的价值也不确定。
方法
对 23 年来在一个中心通过 Macroduct 收集的临床获得的样本进行的 13785 次汗液测试进行了分析。
结果
汗液氯在生命的头一年趋于下降，缓慢增加直到第四个十年，然后稳定或略有下降。在儿童中，阳性和阴性汗液检测的汗液钠重叠，但在成人中没有。如果汗液检测呈阳性，则氯/钠比值>1 的可能性更高，但大多数比值>1 的患者并非 CF。
结论
汗液氯和钠随年龄变化。汗液钠的测量没有增加鉴别价值。有或没有 CF 的氯/钠比值>1 的患者比例在不同年龄段之间差异很大。
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