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髋关节破坏性关节炎患者的骨密度

Bone mineral density in patients with destructive arthrosis of the hip joint.

作者信息

Okano Kunihiko, Aoyagi Kiyoshi, Enomoto Hiroshi, Osaki Makoto, Chiba Ko, Yamaguchi Kazumasa

机构信息

Department of Orthopedic Surgery, Nagasaki Prefectural Center of Medicine and Welfare for Children, 24-3 Eishohigashimachi, Isahaya, 854-0071, Japan,

出版信息

J Bone Miner Metab. 2014 May;32(3):312-6. doi: 10.1007/s00774-013-0501-6. Epub 2013 Aug 7.

Abstract

Recent reports have shown the existence of subchondral insufficiency fracture in rapidly destructive arthrosis of the hip joint (RDA), and the findings suggest that osteopenia is related to the pathogenesis of the rapid progression of this disease. Therefore, we measured bone mineral density (BMD) in RDA patients. We measured BMD of the lumbar spine, radius, and calcaneus using dual-energy X-ray absorptiometry in 19 patients with RDA and 75 with osteoarthritis of the hip (OA) and compared BMD at different skeletal sites between RDA and OA patients. No significant differences were observed in BMD of the lumbar spine, ultradistal radius, mid-radius, and calcaneous between the RDA and OA groups. Our data suggest that RDA is not accompanied by generalized osteoporosis. Factors other than generalized bone status, for example, BMD around the affected hip joint before destruction, need to be analyzed to elucidate the pathophysiological mechanism of RDA.

摘要

近期报告显示,在髋关节快速破坏性关节病(RDA)中存在软骨下不全骨折,研究结果表明骨质减少与该疾病快速进展的发病机制有关。因此,我们对RDA患者的骨密度(BMD)进行了测量。我们使用双能X线吸收法测量了19例RDA患者以及75例髋关节骨关节炎(OA)患者的腰椎、桡骨和跟骨的骨密度,并比较了RDA患者和OA患者不同骨骼部位的骨密度。RDA组和OA组在腰椎、桡骨远端、桡骨中段和跟骨的骨密度方面未观察到显著差异。我们的数据表明,RDA并不伴有全身性骨质疏松。需要分析除全身骨骼状态之外的其他因素,例如破坏前患侧髋关节周围的骨密度,以阐明RDA的病理生理机制。

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