吡嗪甲酰胺的制备：涉及 N-杂环卡宾（NHC）中间体的反应。
Preparation of pyrazine carboxamides: a reaction involving N-heterocyclic carbene (NHC) intermediates.
机构信息
Department of Chemistry and Biochemistry, Northern Illinois University , DeKalb, Illinois 60115, United States.
出版信息
Org Lett. 2013 Sep 20;15(18):4806-9. doi: 10.1021/ol402200x. Epub 2013 Sep 9.
PMID:24015823
Abstract
In the reactions of 2,3-pyrazinedicarboxylic anhydride with amines and anilines, pyrazine carboxamides are formed in good to excellent yields. A mechanism is proposed involving ring opening of the anhydride and decarboxylation of the heterocyclic ring. Based on other similar heterocyclic decarboxylations, this suggests the involvement of an N-heterocyclic carbene intermediate leading to the product.
摘要
在 2,3-吡嗪二甲酸酐与胺和苯胺的反应中，吡嗪甲酰胺以良好到优异的收率形成。提出了一种涉及酸酐开环和杂环脱羧的机理。基于其他类似的杂环脱羧反应，这表明涉及到导致产物的 N-杂环卡宾中间体。
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