Pallati Pradeep K, Shaligram Abhijit, Shostrom Valerie K, Oleynikov Dmitry, McBride Corrigan L, Goede Matthew R
Department of Surgery, Creighton University Medical Center, Omaha, Nebraska.
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska.
Surg Obes Relat Dis. 2014 May-Jun;10(3):502-7. doi: 10.1016/j.soard.2013.07.018. Epub 2013 Aug 29.
The prevalence of gastroesophageal reflux disease (GERD) in the morbidly obese population is as high as 45%. The objective of this study was to compare the efficacy of various bariatric procedures in the improvement of GERD.
The Bariatric Outcomes Longitudinal Database is a prospective database of patients who undergo bariatric surgery by a participant in the American Society of Metabolic and Bariatric Surgery Center of Excellence program. GERD is graded on a 6-point scale, from 0 (no history of GERD) to 5 (prior surgery for GERD). Patients with GERD severe enough to require medications (grades 2, 3, and 4) from June 2007 to December 2009 are identified; the resolution of GERD is noted based on 6-month follow-up.
Of a total of 116,136 patients, 36,938 patients had evidence of GERD preoperatively. After excluding patients undergoing concomitant hiatal hernia repair or fundoplication, there were 22,870 patients with 6-month follow-up. Mean age was 47.6±11.1 years, with an 82% female population. Mean BMI was 46.3±8.0 kg/m(2). Mean preoperative GERD score for patients with Roux-en-Y gastric bypass (RYGB) was 2.80±.56, and mean postoperative score was 1.33±1.41 (P<.0001). Similarly, adjustable gastric banding (AGB, 2.77±.57 to 1.63±1.37, P<.0001) and sleeve gastrectomy (SG, 2.82±.57 to 1.85±1.40, P<.0001) had significant improvement in GERD score. GERD score improvement was best in RYGB patients (56.5%; 7955 of 14,078) followed by AGB (46%; 3773 of 8207) and SG patients (41%; 240 of 585).
All common bariatric procedures improve GERD. Roux-en-Y gastric bypass is superior to adjustable gastric banding and sleeve gastrectomy in improving GERD. Also, the greater the loss in excess weight, the greater the improvement in GERD score.
病态肥胖人群中胃食管反流病(GERD)的患病率高达45%。本研究的目的是比较各种减肥手术在改善GERD方面的疗效。
减肥手术纵向数据库是一个前瞻性数据库,收录了美国代谢与减肥手术卓越中心项目参与者实施减肥手术的患者。GERD按6分制分级,从0(无GERD病史)到5(既往因GERD接受手术)。确定2007年6月至2009年12月期间GERD严重到需要药物治疗(2、3和4级)的患者;根据6个月的随访记录GERD的缓解情况。
在总共116136例患者中,36938例患者术前有GERD证据。排除同期接受食管裂孔疝修补术或胃底折叠术的患者后,有22870例患者进行了6个月的随访。平均年龄为47.6±11.1岁,女性占82%。平均体重指数为46.3±8.0kg/m²。Roux-en-Y胃旁路术(RYGB)患者术前GERD平均评分为2.80±0.56,术后平均评分为1.33±1.41(P<0.0001)。同样,可调节胃束带术(AGB,从2.77±0.57降至1.63±1.37,P<0.0001)和袖状胃切除术(SG,从2.82±0.57降至1.85±1.40,P<0.0001)的GERD评分也有显著改善。RYGB患者的GERD评分改善最佳(56.5%;14078例中的7955例),其次是AGB(46%;8207例中的3773例)和SG患者(41%;585例中的240例)。
所有常见的减肥手术都能改善GERD。Roux-en-Y胃旁路术在改善GERD方面优于可调节胃束带术和袖状胃切除术。此外,超重减轻得越多,GERD评分改善得就越大。