Department of Urology, Weill Cornell Medical College, New York, NY.
Urology. 2013 Dec;82(6):1323-9. doi: 10.1016/j.urology.2013.07.048.
To report oncologic outcomes and complications after robotic-assisted radical cystectomy (RARC).
From March 2004 to August 2011, 175 consecutive patients underwent RARC with extracorporeal urinary diversion at our institution by a single surgeon. The study design was prospective. Perioperative parameters and postoperative complications were prospectively collected using the modified Clavien system. Recurrence-free survival and cancer-specific survival curves were generated using the Kaplan-Meier method.
A total of 145 men and 30 women with a median age of 73 years and a median body mass index of 27 kg/m(2) underwent RARC. Four patients (2.3%) required conversion to open surgery because of difficulty to progress. One hundred nine patients (62%) underwent a transcutaneous ileal conduit, 40 patients (23%) an orthotopic neobladder, and 26 (15%) a continent cutaneous conduit. The median operating time was 360 minutes (interquartile range [IQR]: 300-420). The median estimated blood loss was 400 mL (IQR: 250-612), with a transfusion rate of 17.0%. The median postoperative length of stay was 7.0 days (IQR: 5.2-10). Early (<30 days) and late surgery-related complications (30-90 days) occurred in 74 (42%) and 59 (34%) patients, respectively. The perioperative mortality rate was 2.8%. The positive soft tissue surgical margins rate was 5%. The median number of lymph nodes removed was 19 (IQR: 12-28). The median follow-up was 37 months (IQR: 21.5-53.5). Actuarial recurrence-free survival and cancer-specific survival at 2, 3, and 5 years after RARC were 67%, 63%, 63% and 73%, 68%, 66%, respectively.
RARC achieved mid-term oncologic efficacy. Moreover, the complication rates were comparable with open radical cystectomy series.
报告机器人辅助根治性膀胱切除术(RARC)后的肿瘤学结果和并发症。
从 2004 年 3 月至 2011 年 8 月,我们的机构由一位外科医生对 175 例连续患者进行了 RARC 并进行了体外尿路转流。研究设计为前瞻性。使用改良的 Clavien 系统前瞻性收集围手术期参数和术后并发症。使用 Kaplan-Meier 方法生成无复发生存和癌症特异性生存曲线。
共有 145 名男性和 30 名女性,中位年龄为 73 岁,中位体重指数为 27kg/m²。由于进展困难,4 名患者(2.3%)需要转为开放手术。109 名患者(62%)接受了经皮回肠造口术,40 名患者(23%)接受了原位新膀胱,26 名患者(15%)接受了continent 皮肤造口术。中位手术时间为 360 分钟(四分位距 [IQR]:300-420)。中位估计出血量为 400ml(IQR:250-612),输血率为 17.0%。中位术后住院时间为 7.0 天(IQR:5.2-10)。早期(<30 天)和晚期(30-90 天)手术相关并发症分别发生在 74 名(42%)和 59 名(34%)患者中。围手术期死亡率为 2.8%。阳性软组织手术切缘率为 5%。中位淋巴结切除数为 19(IQR:12-28)。中位随访时间为 37 个月(IQR:21.5-53.5)。RARC 后 2、3 和 5 年的估计无复发生存率和癌症特异性生存率分别为 67%、63%、63%和 73%、68%、66%。
RARC 达到了中期肿瘤学疗效。此外,并发症发生率与开放性根治性膀胱切除术系列相当。