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机器人辅助根治性膀胱切除术联合体外尿流改道术治疗膀胱尿路上皮癌:175 例患者的中位随访时间为 3 年,分析并发症和肿瘤学结果。

Robotic-assisted radical cystectomy with extracorporeal urinary diversion for urothelial carcinoma of the bladder: analysis of complications and oncologic outcomes in 175 patients with a median follow-up of 3 years.

机构信息

Department of Urology, Weill Cornell Medical College, New York, NY.

出版信息

Urology. 2013 Dec;82(6):1323-9. doi: 10.1016/j.urology.2013.07.048.

Abstract

OBJECTIVE

To report oncologic outcomes and complications after robotic-assisted radical cystectomy (RARC).

MATERIALS AND METHODS

From March 2004 to August 2011, 175 consecutive patients underwent RARC with extracorporeal urinary diversion at our institution by a single surgeon. The study design was prospective. Perioperative parameters and postoperative complications were prospectively collected using the modified Clavien system. Recurrence-free survival and cancer-specific survival curves were generated using the Kaplan-Meier method.

RESULTS

A total of 145 men and 30 women with a median age of 73 years and a median body mass index of 27 kg/m(2) underwent RARC. Four patients (2.3%) required conversion to open surgery because of difficulty to progress. One hundred nine patients (62%) underwent a transcutaneous ileal conduit, 40 patients (23%) an orthotopic neobladder, and 26 (15%) a continent cutaneous conduit. The median operating time was 360 minutes (interquartile range [IQR]: 300-420). The median estimated blood loss was 400 mL (IQR: 250-612), with a transfusion rate of 17.0%. The median postoperative length of stay was 7.0 days (IQR: 5.2-10). Early (<30 days) and late surgery-related complications (30-90 days) occurred in 74 (42%) and 59 (34%) patients, respectively. The perioperative mortality rate was 2.8%. The positive soft tissue surgical margins rate was 5%. The median number of lymph nodes removed was 19 (IQR: 12-28). The median follow-up was 37 months (IQR: 21.5-53.5). Actuarial recurrence-free survival and cancer-specific survival at 2, 3, and 5 years after RARC were 67%, 63%, 63% and 73%, 68%, 66%, respectively.

CONCLUSION

RARC achieved mid-term oncologic efficacy. Moreover, the complication rates were comparable with open radical cystectomy series.

摘要

目的

报告机器人辅助根治性膀胱切除术(RARC)后的肿瘤学结果和并发症。

材料和方法

从 2004 年 3 月至 2011 年 8 月,我们的机构由一位外科医生对 175 例连续患者进行了 RARC 并进行了体外尿路转流。研究设计为前瞻性。使用改良的 Clavien 系统前瞻性收集围手术期参数和术后并发症。使用 Kaplan-Meier 方法生成无复发生存和癌症特异性生存曲线。

结果

共有 145 名男性和 30 名女性,中位年龄为 73 岁,中位体重指数为 27kg/m²。由于进展困难,4 名患者(2.3%)需要转为开放手术。109 名患者(62%)接受了经皮回肠造口术,40 名患者(23%)接受了原位新膀胱,26 名患者(15%)接受了continent 皮肤造口术。中位手术时间为 360 分钟(四分位距 [IQR]:300-420)。中位估计出血量为 400ml(IQR:250-612),输血率为 17.0%。中位术后住院时间为 7.0 天(IQR:5.2-10)。早期(<30 天)和晚期(30-90 天)手术相关并发症分别发生在 74 名(42%)和 59 名(34%)患者中。围手术期死亡率为 2.8%。阳性软组织手术切缘率为 5%。中位淋巴结切除数为 19(IQR:12-28)。中位随访时间为 37 个月(IQR:21.5-53.5)。RARC 后 2、3 和 5 年的估计无复发生存率和癌症特异性生存率分别为 67%、63%、63%和 73%、68%、66%。

结论

RARC 达到了中期肿瘤学疗效。此外,并发症发生率与开放性根治性膀胱切除术系列相当。

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