痛风石检测——双能 CT（DECT）与组织学的对比。
Gout tophus detection-a comparison of dual-energy CT (DECT) and histology.
机构信息
Clinic of Rheumatology, Luzerner Kantonsspital, 6000 Lucerne 16, Switzerland.
Institute of Pathology, Luzerner Kantonsspital, Lucerne, Switzerland.
出版信息
Semin Arthritis Rheum. 2014 Apr;43(5):662-5. doi: 10.1016/j.semarthrit.2013.11.002. Epub 2013 Nov 12.
OBJECTIVES
To compare dual-energy CT images (DECT) directly with gold standard histology.
METHODS
A 85-year-old woman with chronic recurrent gouty arthritis and macroscopically visible tophi was assessed with DECT-scans of her feet. When she died 7 days later, three tophi in different regions and in different tissues of her left foot were processed for histological examination.
RESULTS
Of the selected tophi, two were almost completely missed by the color-coding DECT sequences. The tophi remained in most of their volume below the detection threshold value of 150HU (default value).
CONCLUSIONS
It could be demonstrated that DECT only highlights the dense tophi (corresponding of approximately 15-20vol% urate in the tophus). Less dense tophi, despite considerable size, will be missed in the color-coded images.
目的
直接将双能 CT 图像（DECT）与金标准组织病理学进行比较。
方法
对一名 85 岁的慢性复发性痛风性关节炎且有肉眼可见痛风石的女性进行足部 DECT 扫描。7 天后，当她去世时，对其左脚的三个不同部位和不同组织的痛风石进行了组织学检查。
结果
在所选择的痛风石中，有两个几乎完全被彩色编码的 DECT 序列漏诊。这些痛风石的大部分体积仍低于 150HU（默认值）的检测阈值。
结论
可以证明 DECT 仅突出显示高密度痛风石（痛风石中尿酸盐的含量约为 15-20vol%）。尽管体积较大，但密度较低的痛风石会在彩色编码图像中漏诊。
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