一项城市急诊部门内 HIVHCV 的匿名无关联血清流行率调查。

An anonymous unlinked sero-prevalence survey of HIVHCV in an urban Emergency Department.

机构信息

St Michael's Medical Center, Department of Medicine, Division of Infectious Diseases, 111 Central Avenue, Newark, NJ 07101, United States; UMDNJ, New Jersey Medical School, Department of Medicine, 185 South Orange Avenue, Newark, NJ 07103, United States.

UMDNJ, Robert Wood Johnson Medical School, Department of Pathology and Laboratory Medicine, 1 World's Fair Drive, Somerset, NJ 08873, United States.

出版信息

J Clin Virol. 2013 Dec;58 Suppl 1:e19-23. doi: 10.1016/j.jcv.2013.08.025.

DOI:10.1016/j.jcv.2013.08.025

PMID:24342474

Abstract

BACKGROUND

In 2002, the sero-prevalence of human immunodeficiency virus-1 (HIV) in the Emergency Department (ED), University Hospital, Newark, New Jersey was 10.4%. Both HIV and hepatitis C virus (HCV) are transmitted by injection drug use (IDU) or sexual contact. However, the degree of concurrent positive HCV antibody status in HIV-infected ED patients is unknown.

OBJECTIVES

In this study we determined the sero-prevalence of HIV and HIVHCV in HIV-positive patients in the ED.

STUDY DESIGN

A cross-sectional study using an anonymous sero-prevalence survey was conducted from 7/1/2008 to 8/23/2008. Medical records were reviewed and de-identified; remnant blood specimens were also de-identified and tested for HIV antibody, and if positive, HCV antibody.

RESULTS

Of 3488 specimens, 225 (6.5%, 95% CI: 5.7-7.3%) were positive for HIV antibody. Seventy-four patients 74/225 (32.9%, 95% CI: 33.8-46.5%) were unaware of their sero-positivity. Forty percent of HIV positive patients (90/225, 95% CI: 33.8-46.5%) were HCV antibody positive. The highest seroprevalence of HIVHCV antibody was among older patients (≥ 45 years), and patients with positive urine toxicology and elevated liver function tests.

DISCUSSION

Given the high prevalence of HIV and HIVHCV antibody in the ED, routine testing is important for patients ≥ 45 years with positive urine toxicology and elevated liver function tests.

摘要

背景

2002 年，新泽西州纽瓦克大学医院急诊部（ED）人类免疫缺陷病毒-1（HIV）的血清阳性率为 10.4%。HIV 和丙型肝炎病毒（HCV）均通过注射吸毒或性接触传播。然而，HIV 感染的 ED 患者中同时存在 HCV 抗体阳性的程度尚不清楚。

目的

本研究旨在确定 ED 中 HIV 阳性患者的 HIV 和 HIVHCV 的血清阳性率。

研究设计

2008 年 7 月 1 日至 8 月 23 日进行了一项横断面研究，采用匿名血清阳性率调查。对病历进行了回顾和去识别；剩余的血液标本也进行了去识别，并进行了 HIV 抗体检测，如果阳性，则进行 HCV 抗体检测。

结果

在 3488 份标本中，225 份（6.5%，95%CI：5.7-7.3%）HIV 抗体阳性。74 例患者（74/225，32.9%，95%CI：33.8-46.5%）不知道自己的血清阳性。40%的 HIV 阳性患者（90/225，95%CI：33.8-46.5%）HCV 抗体阳性。HIVHCV 抗体的最高血清阳性率见于年龄较大的患者（≥45 岁）和尿液毒物检测阳性且肝功能检查升高的患者。