多次呼吸冲洗在临床环境中是可行的，并可检测出囊性纤维化的婴儿和幼儿的异常肺功能。
Multiple breath washout is feasible in the clinical setting and detects abnormal lung function in infants and young children with cystic fibrosis.
机构信息
Division of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Pediatrics, German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.
出版信息
Respiration. 2014;87(5):357-63. doi: 10.1159/000357075. Epub 2014 Jan 14.
BACKGROUND
Cystic fibrosis (CF) lung disease starts in the first months of life often before the onset of clinical symptoms. Multiple breath washout (MBW) detects abnormal lung function in infants and young children in the laboratory setting.
OBJECTIVE
The aim of this study was to determine the feasibility of MBW in 0- to 4-year-old children with CF and non-CF controls in the clinical setting.
METHODS
Fourteen children with CF (mean age 1.3 ± 1.0 years) and 26 age-matched non-CF controls were sedated with chloral hydrate and MBW was performed with sulfur hexafluoride.
RESULTS
MBW measurements were successful in 27 of 40 children (67.5%). The mean lung clearance index (LCI) was significantly higher in CF patients compared to non-CF controls (p = 0.006). Further, the frequency of elevated LCI (z-score >1.96) was significantly increased in CF patients compared to controls (p = 0.0003).
CONCLUSIONS
We conclude that MBW is feasible and sensitive to detect abnormal lung function in infants and young children with CF in the clinical setting.
背景
囊性纤维化（CF）肺病始于生命的头几个月，通常在出现临床症状之前。多次呼吸冲洗（MBW）在实验室环境中检测婴儿和幼儿的异常肺功能。
目的
本研究旨在确定 MBW 在 CF 和非 CF 对照 0 至 4 岁儿童中的临床可行性。
方法
14 名 CF 患儿（平均年龄 1.3 ± 1.0 岁）和 26 名年龄匹配的非 CF 对照组患儿接受水合氯醛镇静，并用六氟化硫进行 MBW。
结果
40 名儿童中有 27 名（67.5%）MBW 测量成功。与非 CF 对照组相比，CF 患者的平均肺清除指数（LCI）显着升高（p = 0.006）。此外，CF 患者中 LCI 升高（z 分数>1.96）的频率显着高于对照组（p = 0.0003）。
结论
我们得出结论，MBW 是可行的，并且可以在临床环境中检测 CF 婴儿和幼儿的异常肺功能。
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