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论梅达沃的“对外来细胞的主动获得性耐受”。

On Medawar's 'Actively acquired tolerance of foreign cells'.

机构信息

Stem Cell Institute and Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.

出版信息

Exp Dermatol. 2014 Feb;23(2):97-8. doi: 10.1111/exd.12227.

Abstract

The fields of dermatology and transplantation biology have recently come together in clinical trials of bone marrow transplantation for severe inherited blistering skin diseases. But the original link between these two disciplines goes back to an extraordinary publication in 1953 in Nature by Peter Medawar and colleagues that explored the immunological basis of successful skin transplantation between different strains of mice and how 'foreign' antigens could be perceived as 'self'. This work led to the emergence of blood and bone marrow transplantation and thus transformed the practice of modern medicine.

摘要

皮肤病学和移植生物学领域最近在骨髓移植治疗严重遗传性水疱性皮肤病的临床试验中结合在一起。但这两个学科之间的最初联系可以追溯到彼得·梅达沃(Peter Medawar)及其同事在 1953 年发表于《自然》(Nature)杂志上的一篇非凡论文,该论文探讨了不同品系小鼠之间成功的皮肤移植的免疫学基础,以及“外来”抗原如何被视为“自身”。这项工作导致了血液和骨髓移植的出现,从而改变了现代医学的实践。

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