OncomiRDB：一个经实验验证的致癌和肿瘤抑制 microRNA 的数据库。

OncomiRDB: a database for the experimentally verified oncogenic and tumor-suppressive microRNAs.

机构信息

MOE Key Laboratory of Bioinformatics, TNLIST Bioinformatics Division / Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.

出版信息

Bioinformatics. 2014 Aug 1;30(15):2237-8. doi: 10.1093/bioinformatics/btu155. Epub 2014 Mar 20.

DOI:10.1093/bioinformatics/btu155

PMID:24651967

Abstract

SUMMARY

MicroRNAs (miRNAs), a class of small regulatory RNAs, play important roles in cancer initiation, progression and therapy. MiRNAs are found to regulate diverse cancer-related processes by targeting a large set of oncogenic and tumor-suppressive genes. To establish a high-confidence reference resource for studying the miRNA-regulated target genes and cellular processes in cancer, we manually curated 2259 entries of cancer-related miRNA regulations with direct experimental evidence from ∼9000 abstracts, covering more than 300 miRNAs and 829 target genes across 25 cancer tissues. A web-based portal named oncomiRDB, which provides both graphical and text-based interfaces, was developed for easily browsing and searching all the annotations. It should be a useful resource for both the computational analysis and experimental study on miRNA regulatory networks and functions in cancer.

AVAILABILITY AND IMPLEMENTATION

http://bioinfo.au.tsinghua.edu.cn/oncomirdb/

CONTACT

jgu@tsinghua.edu.cn

SUPPLEMENTARY INFORMATION

Supplementary data are available at Bioinformatics online.

摘要

MicroRNAs（miRNAs）是一类小的调节性 RNA，在癌症的发生、发展和治疗中发挥着重要作用。miRNAs 通过靶向一大组致癌和肿瘤抑制基因，被发现调节多种与癌症相关的过程。为了建立一个研究癌症中 miRNA 调节靶基因和细胞过程的高可信度参考资源，我们从约 9000 篇摘要中手动整理了 2259 项具有直接实验证据的癌症相关 miRNA 调控条目，涵盖了超过 300 种 miRNA 和 829 个靶基因，涉及 25 种癌症组织。我们开发了一个名为 oncomiRDB 的基于网络的门户，它提供了图形和基于文本的界面，用于方便地浏览和搜索所有注释。它应该是 miRNA 调控网络和功能在癌症中的计算分析和实验研究的有用资源。