先进脉冲激光技术制备的抗菌纳米球薄膜涂层。
Antimicrobial nanospheres thin coatings prepared by advanced pulsed laser technique.
机构信息
University of Bucharest, Faculty of Biology, Microbiology Department, Aleea Portocalelor no 1-3, 060101 Bucharest, Romania.
University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, Polizu Street no 1-7, 011061 Bucharest, Romania ; National Institute for Lasers, Plasma & Radiation Physics, Lasers Department, P.O.Box MG-36, Bucharest-Magurele, Romania.
出版信息
Beilstein J Nanotechnol. 2014 Jun 18;5:872-80. doi: 10.3762/bjnano.5.99. eCollection 2014.
We report on the fabrication of thin coatings based on polylactic acid-chitosan-magnetite-eugenol (PLA-CS-Fe3O4@EUG) nanospheres by matrix assisted pulsed laser evaporation (MAPLE). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) investigation proved that the homogenous Fe3O4@EUG nanoparticles have an average diameter of about 7 nm, while the PLA-CS-Fe3O4@EUG nanospheres diameter sizes range between 20 and 80 nm. These MAPLE-deposited coatings acted as bioactive nanosystems and exhibited a great antimicrobial effect by impairing the adherence and biofilm formation of Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) bacteria strains. Moreover, the obtained nano-coatings showed a good biocompatibility and facilitated the normal development of human endothelial cells. These nanosystems may be used as efficient alternatives in treating and preventing bacterial infections.
我们通过基质辅助脉冲激光蒸发 (MAPLE) 法报告了基于聚乳酸-壳聚糖-磁铁矿-丁香酚 (PLA-CS-Fe3O4@EUG) 纳米球的薄膜的制备。透射电子显微镜 (TEM) 和扫描电子显微镜 (SEM) 研究证明，均匀的 Fe3O4@EUG 纳米颗粒的平均直径约为 7nm，而 PLA-CS-Fe3O4@EUG 纳米球的直径尺寸在 20nm 到 80nm 之间。这些 MAPLE 沉积的涂层作为生物活性纳米系统，通过损害金黄色葡萄球菌 (S. aureus) 和铜绿假单胞菌 (P. aeruginosa) 细菌菌株的粘附和生物膜形成，表现出很强的抗菌效果。此外，所得到的纳米涂层具有良好的生物相容性，并促进了人内皮细胞的正常发育。这些纳米系统可作为治疗和预防细菌感染的有效替代品。
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