用于传染病研究的基于噬菌体的合成生物学
Bacteriophage-based synthetic biology for the study of infectious diseases.
作者信息
Citorik Robert J, Mimee Mark, Lu Timothy K
机构信息
MIT Microbiology Program, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
MIT Synthetic Biology Center, 500 Technology Square, Cambridge, MA 02139, USA.
出版信息
Curr Opin Microbiol. 2014 Jun;19:59-69. doi: 10.1016/j.mib.2014.05.022. Epub 2014 Jul 3.
Since their discovery, bacteriophages have contributed enormously to our understanding of molecular biology as model systems. Furthermore, bacteriophages have provided many tools that have advanced the fields of genetic engineering and synthetic biology. Here, we discuss bacteriophage-based technologies and their application to the study of infectious diseases. New strategies for engineering genomes have the potential to accelerate the design of novel phages as therapies, diagnostics, and tools. Though almost a century has elapsed since their discovery, bacteriophages continue to have a major impact on modern biological sciences, especially with the growth of multidrug-resistant bacteria and interest in the microbiome.
自噬菌体被发现以来，它们作为模型系统，为我们理解分子生物学做出了巨大贡献。此外，噬菌体还提供了许多推动基因工程和合成生物学领域发展的工具。在这里，我们将讨论基于噬菌体的技术及其在传染病研究中的应用。基因组工程的新策略有可能加速新型噬菌体作为治疗、诊断和工具的设计。尽管自噬菌体被发现以来已过去近一个世纪，但它们仍对现代生物科学产生重大影响，尤其是在多重耐药细菌不断增加以及人们对微生物组兴趣浓厚的情况下。
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