中性粒细胞明胶酶相关脂质运载蛋白（NGAL）与老年期抑郁症认知领域之间的性别特异性关联。
Sex-specific associations between Neutrophil Gelatinase-Associated Lipocalin (NGAL) and cognitive domains in late-life depression.
作者信息
Naudé P J W, den Boer J A, Comijs H C, Bosker F J, Zuidersma M, Groenewold N A, De Deyn P P, Luiten P G M, Eisel U L M, Oude Voshaar R C
机构信息
Department of Molecular Neurobiology, University of Groningen, Groningen, The Netherlands; University Center of Psychiatry & Interdisciplinary Center of Psychopathology of Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Neurology and Alzheimer Research Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, The Netherlands.
出版信息
Psychoneuroendocrinology. 2014 Oct;48:169-77. doi: 10.1016/j.psyneuen.2014.06.016. Epub 2014 Jun 27.
BACKGROUND
Although it is well established that late-life depression is associated with both systemic low-graded inflammation and cognitive impairment, the relation between inflammation and cognition in depressed older persons is still equivocal. The objective of this study is to examine the association between plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) concentrations and cognitive functioning in late-life depression, including the potentially moderating role of sex.
METHODS
A total of 369 depressed older persons (≥60 years) from The Netherlands study of Depression in Older persons (NESDO) were included. Four cognitive domains, i.e. verbal memory, processing speed, interference control and attention were assessed with three cognitive tests (Stroop test, Wais Digit span test, and Rey's verbal learning test). Multiple linear regression analyses were applied with the four cognitive domains as dependent variables adjusted for confounders.
RESULTS
The association between NGAL levels and specific cognitive domains were sex-specific. In women, higher NGAL levels were associated with impaired verbal memory and lower processing speed. In men, higher NGAL levels were associated with worse interference control. Higher NGAL levels were not associated with attention. No sex-specific associations of either high sensitivity C-reactive protein (hsCRP) or interleukin-6 (IL-6) with cognitive functioning were found.
CONCLUSION
This study shows sex-specific association of NGAL with cognitive functioning in late-life depression.
背景
尽管已有充分证据表明晚年抑郁症与全身性低度炎症及认知障碍均相关，但抑郁症老年患者炎症与认知之间的关系仍不明确。本研究的目的是探讨血浆中性粒细胞明胶酶相关脂质运载蛋白（NGAL）浓度与晚年抑郁症认知功能之间的关联，包括性别可能起到的调节作用。
方法
纳入了来自荷兰老年人抑郁症研究（NESDO）的369名年龄≥60岁的抑郁症老年患者。通过三项认知测试（斯特鲁普测试、韦氏数字广度测试和雷伊言语学习测试）评估了四个认知领域，即言语记忆、处理速度、干扰控制和注意力。以这四个认知领域为因变量，应用多元线性回归分析，并对混杂因素进行了校正。
结果
NGAL水平与特定认知领域之间的关联存在性别差异。在女性中，较高的NGAL水平与言语记忆受损及处理速度降低有关。在男性中，较高的NGAL水平与较差的干扰控制有关。较高的NGAL水平与注意力无关。未发现高敏C反应蛋白（hsCRP）或白细胞介素-6（IL-6）与认知功能存在性别特异性关联。
结论
本研究表明在晚年抑郁症中，NGAL与认知功能存在性别特异性关联。
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