KIR B单倍型供体可降低儿童急性淋巴细胞白血病单倍体相合移植后复发风险。
KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL.
作者信息
Oevermann Lena, Michaelis Sebastian U, Mezger Markus, Lang Peter, Toporski Jacek, Bertaina Alice, Zecca Marco, Moretta Lorenzo, Locatelli Franco, Handgretinger Rupert
机构信息
Children's Hospital, University of Tübingen, Germany;
Department of Pediatric Oncology, University Hospital Lund, Sweden;
出版信息
Blood. 2014 Oct 23;124(17):2744-7. doi: 10.1182/blood-2014-03-565069. Epub 2014 Aug 12.
We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free survival (EFS) in children with acute lymphoblastic leukemia who received human leukocyte antigen-haploidentical transplantation of ex vivo T-cell-depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors, and the KIR B content score was determined in the 63 KIR haplotype B donors. Patients transplanted from a KIR haplotype B donor had a significantly better EFS than those transplanted from a KIR haplotype A donor (50.6% vs 29.5%, respectively; P = .033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk for relapse (Log-rank test for trend, P = .026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with acute lymphoblastic leukemia with the aim of choosing, whenever possible, a KIR haplotype B donor with a high KIR B-content score.
我们分析了供体杀伤细胞免疫球蛋白样受体（KIR）基因单倍型对接受人白细胞抗原半相合、体外去除T细胞的外周血干细胞移植的急性淋巴细胞白血病患儿复发风险和无事件生存（EFS）概率的影响。对85名供体的KIR基因单倍型进行了评估，并在63名KIR单倍型B供体中确定了KIR B含量评分。与接受KIR单倍型A供体移植的患者相比，接受KIR单倍型B供体移植的患者的EFS显著更好（分别为50.6%和29.5%；P = 0.033）。此外，供体KIR B含量评分高与复发风险显著降低相关（趋势对数秩检验，P = 0.026）。这些数据表明，在急性淋巴细胞白血病患儿半相合移植的供体选择算法中应纳入KIR基因分型，目的是尽可能选择KIR B含量评分高的KIR单倍型B供体。
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