金催化的烯烃与二烷氨基苯的氢芳基化反应。
Gold-catalyzed hydroarylation of alkenes with dialkylanilines.
机构信息
UCSD-CNRS Joint Research Laboratory (UMI 3555), Department of Chemistry and Biochemistry, University of California, San Diego , La Jolla, California 92093-0343, United States.
出版信息
J Am Chem Soc. 2014 Oct 1;136(39):13594-7. doi: 10.1021/ja507788r. Epub 2014 Sep 19.
Anti-Bredt di(amino)carbene supported gold(I) chloride complexes are readily prepared in two steps from the corresponding isocyanide complexes. In the presence of KB(C6F5)4 as chloride scavenger, they promote the unprecedented hydroarylation reaction of alkenes with N,N-dialkylanilines with high para-selectivity. The latter are challenging arenes for Friedel-Craft reactions, due to their high basicity.
反-Bredt 二（氨基）碳烯负载的金（I）氯化物配合物可通过两步反应从相应的异氰化物配合物轻易制备得到。在 KB(C6F5)4 作为氯化物清除剂的存在下，它们促进了烯烃与 N,N-二烷基苯胺的空前的氢芳基化反应，具有高的对位选择性。后者是由于其高碱性而对 Friedel-Craft 反应具有挑战性的芳环。
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