伴有外周血受累的滤泡性淋巴瘤的临床病理特征
Clinicopathological characteristics of follicular lymphoma with peripheral blood involvement.
作者信息
Maeshima Akiko Miyagi, Taniguchi Hirokazu, Tanioka Kensaku, Kitahara Hideaki, Miyamoto Ken-Ichi, Fukuhara Suguru, Munakata Wataru, Suzuki Tatsuya, Maruyama Dai, Kobayashi Yukio, Tobinai Kensei, Kushima Ryoji
机构信息
Department of Pathology and Clinical Laboratory.
出版信息
Leuk Lymphoma. 2015 Jul;56(7):2000-4. doi: 10.3109/10428194.2014.963578. Epub 2014 Nov 14.
This study aimed to indicate patient outcomes and pathological characteristics of follicular lymphoma (FL) with peripheral blood (PB) involvement. Of 533 patients with FL, 56 (11%) had PB involvement. Of the patients treated with rituximab, 39 patients with PB involvement had significantly shorter progression-free survival than 107 patients with stage IV disease without PB involvement (p = 0.021), but the overall survival was not different (p = 0.804). The histopathology of the primary sites was usually nodal (95%) low-grade (86%) FL with IGH/BCL2 fusion (75%). Flow cytometric and immunohistochemical analyses revealed that the incidence of CD10 positivity was lower in the bone marrow (55% and 58%) and PB (41% and not available) than in the primary site (86% and 93%) (p = 0.004 and p = 0.0001, respectively). Therefore, even if small lymphoma cells in the bone marrow and PB are negative for CD10, FL cannot be ruled out.
本研究旨在阐明伴有外周血（PB）受累的滤泡性淋巴瘤（FL）患者的预后及病理特征。在533例FL患者中，56例（11%）存在PB受累。在接受利妥昔单抗治疗的患者中，39例PB受累患者的无进展生存期显著短于107例IV期无PB受累疾病患者（p = 0.021），但总生存期无差异（p = 0.804）。原发部位的组织病理学通常为淋巴结（95%）、低级别（86%）FL伴IGH/BCL2融合（75%）。流式细胞术和免疫组化分析显示，骨髓（55%和58%）和PB（41%且数据不可用）中CD10阳性的发生率低于原发部位（86%和93%）（分别为p = 0.004和p = 0.0001）。因此，即使骨髓和PB中的小淋巴瘤细胞CD10呈阴性，也不能排除FL。
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