加巴喷丁和普瑞巴林对大鼠伤口愈合影响的比较。
Comparison of the effects of gabapentin and pregabalin on wound healing in rats.
作者信息
Sarıtaş Tuba Berra, Korkmaz Musa, Sevimli Alper, Sarıtaş Zulfikar Kadir
机构信息
Department of Anesthesiology and Reanimation, Meram Medical School, Necmettin Erbakan University, Konya, Turkey.
Department of Surgery, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
出版信息
Int Wound J. 2016 Oct;13(5):748-53. doi: 10.1111/iwj.12364. Epub 2014 Oct 28.
Gabapentinoids are effective adjunct drugs for reducing postoperative pain. However, the effects of gabapentinoids on wound healing have not been evaluated yet. In this study we evaluated their effects on wound healing. A total of 17 male Wistar-Albino rats, 250-350 g, were divided into three groups randomly: control group (n = 5, 2 ml saline), gabapentin group (n = 6, 20 mg/kg gabapentin) and pregabalin group (n = 6, 20 mg/kg pregabalin). Until day 13 inflammation scores were significantly lower (P < 0·05) and wound healing was significantly better in the control group when compared with gabapentin and pregabalin groups (P < 0·001). Inflammation scores were significantly lower in pregabalin group when compared with gabapentin group until day 13. But wound healing was significantly better in gabapentin group than in pregabalin group between days 13 and 21. In conclusion when gabapentin and pregabalin were compared, although pregabalin decreases inflammation scores, gabapentin has better results in wound healing.
加巴喷丁类药物是减轻术后疼痛的有效辅助药物。然而，加巴喷丁类药物对伤口愈合的影响尚未得到评估。在本研究中，我们评估了它们对伤口愈合的影响。总共17只体重250 - 350克的雄性Wistar - Albino大鼠被随机分为三组：对照组（n = 5，2毫升生理盐水）、加巴喷丁组（n = 6，20毫克/千克加巴喷丁）和普瑞巴林组（n = 6，20毫克/千克普瑞巴林）。直到第13天，与加巴喷丁组和普瑞巴林组相比，对照组的炎症评分显著更低（P < 0·05），伤口愈合明显更好（P < 0·001）。直到第13天，与加巴喷丁组相比，普瑞巴林组的炎症评分显著更低。但在第13天至21天之间，加巴喷丁组的伤口愈合明显优于普瑞巴林组。总之，比较加巴喷丁和普瑞巴林时，虽然普瑞巴林降低了炎症评分，但加巴喷丁在伤口愈合方面有更好的效果。
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