“开-关-开”型可切换传感器：一种对极端 pH 值条件有响应的荧光螺吡喃及其生物成像应用。
"On-off-on" switchable sensor: a fluorescent spiropyran responds to extreme pH conditions and its bioimaging applications.
机构信息
State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, China.
出版信息
ACS Appl Mater Interfaces. 2014 Nov 26;6(22):19515-9. doi: 10.1021/am506641t. Epub 2014 Nov 17.
A novel spiropyran that responds to both extreme acid and extreme alkali and has an "on-off-on" switch is reported. Benzoic acid at the indole N-position and carboxyl group at the indole 6-position contribute to the extreme acid response. The ionizations of carboxyl and phenolic hydroxyl groups cause the extreme alkali response. Moreover, the fluorescent imaging in bacterial cells under extreme pH conditions supports the mechanism of pH response.
报道了一种对极端酸和极端碱都有响应且具有“开-关-开”开关的新型螺吡喃。吲哚 N 位上的苯甲酸和吲哚 6 位上的羧基有助于对极端酸的响应。羧基和酚羟基的离解导致了极端碱的响应。此外，在极端 pH 条件下细菌细胞中的荧光成像支持了 pH 响应的机制。
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