在内毒素攻击的大鼠中，电针足三里穴（ST36）通过激活胆碱能抗炎途径来减轻促炎细胞因子的释放和器官功能障碍。
Electroacupuncturing at Zusanli point (ST36) attenuates pro-inflammatory cytokine release and organ dysfunction by activating cholinergic anti-inflammatory pathway in rat with endotoxin challenge.
作者信息
Song Qi, Hu Sen, Wang Haibin, Lv Yi, Shi Xian, Sheng Ziyong, Sheng Wei
机构信息
The Oncotherapy center of the People's Liberation Army General Hospital, Beijing 100853 PRC.
The Burns Institute, the First Hospital Affiliated to the General Hospital of People's Liberation Army, Beijing 100853 PRC.
出版信息
Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):469-74. doi: 10.4314/ajtcam.v11i2.35. eCollection 2014.
BACKGROUND
It is considered that the pathogenesis is closely related to an excessive production of pro-inflammatory cytokines caused by bacterial toxins and an imbalance between pro-inflammatory and anti-inflammatory mediators.
MATERIALS AND METHODS
This work investigates the effect of electro-acupuncturing (EA), at Zusanli point (ST36) on plasma cytokine release and organ dysfunction and their mechanism in conscious rats with endotoxin challenge.
RESULTS
EA at Zusanli points obviously lowered the elevated levels of plasma TNF-α, and attenuated changes in parameters relevant to various organ functions at 2 h after LPS challenge. α-BGT injection or bilateral cervical vagotomy could weaken or eliminate the effects of EA, and further aggravated the elevated levels of pro-inflammatory cytokines and organ dysfunction.
CONCLUSION
The results suggested that EA at Zusanli points significantly reduced the release of pro-inflammatory cytokines and organ dysfunction after LPS challenge by activating cholinergic anti-inflammatory pathway.
背景
一般认为，发病机制与细菌毒素引起的促炎细胞因子过度产生以及促炎和抗炎介质之间的失衡密切相关。
材料与方法
本研究探讨电针足三里穴（ST36）对脂多糖攻击的清醒大鼠血浆细胞因子释放和器官功能障碍的影响及其机制。
结果
电针足三里穴可显著降低脂多糖攻击2小时后升高的血浆肿瘤坏死因子-α水平，并减轻与各器官功能相关参数的变化。注射α-银环蛇毒素或双侧颈迷走神经切断可减弱或消除电针的作用，并进一步加重促炎细胞因子水平升高和器官功能障碍。
结论
结果表明，电针足三里穴可通过激活胆碱能抗炎通路显著降低脂多糖攻击后促炎细胞因子的释放和器官功能障碍。
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