DNA传感器中的电催化作用。
Electrocatalysis in DNA Sensors.
作者信息
Furst Ariel, Hill Michael G, Barton Jacqueline K
机构信息
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125.
出版信息
Polyhedron. 2014 Dec 14;84:150-159. doi: 10.1016/j.poly.2014.07.005.
Electrocatalysis is often thought of solely in the inorganic realm, most often applied to energy conversion in fuel cells. However, the ever-growing field of bioelectrocatalysis has made great strides in advancing technology for both biofuel cells as well as biological detection platforms. Within the context of bioelectrocatalytic detection systems, DNA-based platforms are especially prevalent. One subset of these platforms, the one we have developed, takes advantage of the inherent charge transport properties of DNA. Electrocatalysis coupled with DNA-mediated charge transport has enabled specific and sensitive detection of lesions, mismatches and DNA-binding proteins. Even greater signal amplification from these platforms is now being achieved through the incorporation of a secondary electrode to the platform both for patterning DNA arrays and for detection. Here, we describe the evolution of this new DNA sensor technology.
电催化通常仅在无机领域被提及，最常用于燃料电池中的能量转换。然而，不断发展的生物电催化领域在推动生物燃料电池以及生物检测平台技术方面取得了巨大进展。在生物电催化检测系统的背景下，基于DNA的平台尤为普遍。我们所开发的这类平台的一个子集利用了DNA固有的电荷传输特性。电催化与DNA介导的电荷传输相结合，实现了对损伤、错配和DNA结合蛋白的特异性和灵敏检测。现在，通过在平台中加入辅助电极用于DNA阵列的图案化和检测，这些平台实现了更大的信号放大。在此，我们描述这种新型DNA传感器技术的发展历程。
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