鬼针草对鸡艾美耳球虫感染及耐药性的影响。

Effect of Bidens pilosa on infection and drug resistance of Eimeria in chickens.

作者信息

Yang W C, Tien Y J, Chung C Y, Chen Y C, Chiou W H, Hsu S Y, Liu H Y, Liang C L, Chang C L T

机构信息

Agricultural Biotechnology Research Center, Academia Sinica, Taiwan; Department of Life Sciences, National Chung Hsing University, Taiwan.

Institute of Statistical Science, Academia Sinica, Taiwan.

出版信息

Res Vet Sci. 2015 Feb;98:74-81. doi: 10.1016/j.rvsc.2014.11.002. Epub 2014 Nov 14.

DOI:10.1016/j.rvsc.2014.11.002

PMID:25440995

Abstract

Extensive use of current anti-coccidial drugs together with drug resistance and residue has raised concerns about public health and poultry development. Here, we studied the anti-coccidial properties of Bidens pilosa. A phytochemical approach was developed for analysis of B. pilosa utilized as a feed additive. The protective effects of B. pilosa supplemented chicken diet were evaluated chickens infected with Eimeria tenella. B. pilosa, at doses of 0.5%, 1% and 5% of the chicken diet, significantly protected against E.tenella as measured by reduction in mortality, weight loss, fecal oocyst excretion and gut pathology in chickens. Finally, drug resistance of E. tenella to B. pilosa was assessed in chickens using the anti-coccidial index. This index showed that B. pilosa induced little, if any, drug resistance to Eimeria in chickens. Collectively, this work suggests that B. pilosa may serve as a novel, natural remedy for coccidiosis with low drug resistance in chickens.

摘要

当前抗球虫药物的广泛使用以及耐药性和药物残留问题引发了对公共卫生和家禽养殖发展的担忧。在此，我们研究了鬼针草的抗球虫特性。开发了一种植物化学方法用于分析用作饲料添加剂的鬼针草。评估了在感染柔嫩艾美耳球虫的鸡中，添加鬼针草的鸡日粮的保护作用。以鸡日粮的0.5%、1%和5%剂量的鬼针草，通过降低鸡的死亡率、体重减轻、粪便卵囊排泄和肠道病理学来衡量，能显著抵抗柔嫩艾美耳球虫。最后，使用抗球虫指数在鸡中评估了柔嫩艾美耳球虫对鬼针草的耐药性。该指数表明，鬼针草对鸡的艾美耳球虫几乎没有诱导耐药性。总体而言，这项研究表明鬼针草可能作为一种新型的、天然的鸡球虫病治疗方法，且对鸡的耐药性较低。